Evidence map›Paper›PMID 31912689›Full record

ArticleJournal of biomedical optics2020

Reactive oxygen species explicit dosimetry to predict tumor growth for benzoporphyrin derivative-mediated vascular photodynamic therapy.

Tianqi Sheng, Yi Hong Ong, Wensheng Guo, Timothy Zhu

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tianqi ShengUniv. of Pennsylvania, United States.
Yi Hong OngUniv. of Pennsylvania, United States.
Wensheng GuoUniv. of Pennsylvania, United States.
Timothy ZhuUniv. of Pennsylvania, United States.
University of Pennsylvania · US

Funding

TUMOR HYPOXIA, PHOTOSENSITIZER, VASCULARITY AND PDTP01CA087971 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M, CENGEL, KEITH A · 2001 to 2019
$24.8M
Development of Novel Fast GPU Monte Carlo and Active Photonics Simulation Software for Predicting PDT EfficacyR44CA183236 · NCI · SIMPHOTEK, INC. · PI CARY, JOHN R, POTASEK, MARY · 2016 to 2017
$1.5M
NCI NIH HHS P01 CA087971NCI NIH HHS R44 CA183236Wellcome Trust
6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a well-established treatment modality for cancer and other malignant diseases; however, quantities such as light fluence and PDT dose do not fully account for all of the dynamic interactions between the key components involved. In particular, fluence rate (ϕ) effects, which impact the photochemical oxygen consumption rate, are not accounted for. In this preclinical study, reacted reactive oxygen species ([ROS]

Indexed as

FibrosarcomaPhotochemotherapyAnimalsMiceMice, Inbred C3HPhotosensitizing AgentsReactive Oxygen SpeciesSinglet OxygenPhotosensitizing AgentsReactive Oxygen SpeciesSinglet Oxygenbenzoporphyrin derivative-mediated PDTexplicit dosimetryin vivo mouse studyPDT dosephotodynamic therapy (PDT)reactive oxygen speciessinglet oxygen

Identifiers

PMID31912689
PMCPMC6952881
OpenAlexW3000633892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.