ArticleJournal of gynecologic oncology2020
Pathologic discrepancies between colposcopy-directed biopsy and loop electrosurgical excision procedure of the uterine cervix in women with cytologic high-grade squamous intraepithelial lesions.
Article in Journal of gynecologic oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Preoperative hematological parameters do not predict lesion severity or recurrence in cervical intraepithelial neoplasia: a retrospective cohort study.Discover oncology · 2026Article
- Analysis of Pathological Discrepancies Between Colposcopic Biopsy and Conization in Cytology-Positive Cervical Lesions.Cancer medicine · 2026Article
- Risk factors of histologic upgrade between colposcopy-directed biopsy and loop electrosurgical excision procedure in cervical squamous intraepithelial lesions: a retrospective study.Frontiers in medicine · 2026Article
- Clinical and prognostic outcomes of colposcopy-guided LEEP versus cold knife conization in the management of cervical intraepithelial neoplasia.Frontiers in oncology · 2025Article
- Article
- PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study.BMC medicine · 2024Article
- Radiomics-based machine learning models for differentiating pathological subtypes in cervical cancer: a multicenter study.Frontiers in oncology · 2024Article
- Prevalence of cervical precancers or cancers in women with ASC-H/HSIL cytology according to Aptima HPV (AHPV) assay-detected HPV genotypes and age.Journal of Cancer · 2024Article
- Quantitative Proteomic Analysis of MCM3 in ThinPrep Samples of Patients with Cervical Preinvasive Cancer.International journal of molecular sciences · 2023Article
- Certification as dysplasia unit and its impact on large loop electrosurgical excision (LEEP).Archives of gynecology and obstetrics · 2023Article
- Cervical Intraepithelial Neoplasia grade 2 biopsy: Do p16INK4a and Ki-67 biomarkers contribute to the decision to treat? A cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2023Article
- Convolutional neural network-based classification of cervical intraepithelial neoplasias using colposcopic image segmentation for acetowhite epithelium.Scientific reports · 2022Article
- Evaluation of the diagnostic accuracy of the cervical biopsy under colposcopic vision.European journal of translational myology · 2022Article
- Midtrimester cervical elastography in pregnant women with a history of loop electrosurgical excision procedure (LEEP).Scientific reports · 2022Article
- Assessing colposcopic accuracy for high-grade squamous intraepithelial lesion detection: a retrospective, cohort study.BMC women's health · 2022Article
- Can biopsies be omitted after normal colposcopy in women referred with low-grade cervical cytology? A prospective cohort study.BMC women's health · 2021Observational
- Histopathological correlation of cervical biopsy and tissue after excision in patients with precancerous lesions of the cervix.Archives of gynecology and obstetrics · 2021Article
- Negative loop electrosurgical excision procedure (LEEP) following cervical biopsy diagnosis of high grade squamous intraepithelial lesion.International journal of clinical and experimental pathology · 2021Article
- Optimizing the Detection of Occult Cervical Cancer: A Prospective Multicentre Study in China.International journal of women's health · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate pathologic discrepancies between colposcopy-directed biopsy (CDB) of the cervix and loop electrosurgical excision procedure (LEEP) in women with cytologic high-grade squamous intraepithelial lesions (HSILs).
methodsWe retrospectively identified 297 patients who underwent both CDB and LEEP for HSILs in cervical cytology between 2015 and 2018, and compared their pathologic results. Considering the LEEP to be the gold standard, we evaluated the diagnostic performance of CDB for identifying cervical intraepithelial neoplasia (CIN) grades 2 and 3, adenocarcinoma in situ, and cancer (HSIL+). We also performed age subgroup analyses.
resultsAmong the study population, 90.9% (270/297) had pathologic HSIL+ using the LEEP. The diagnostic performance of CDB for identifying HSIL+ was as follows: sensitivity, 87.8%; specificity, 59.3%; balanced accuracy, 73.6%; positive predictive value, 95.6%; and negative predictive value, 32.7%. Thirty-three false negative cases of CDB included CIN2,3 (n=29) and cervical cancer (n=4). The pathologic HSIL+ rate in patients with HSIL- by CDB was 67.3% (33/49). CDB exhibited a significant difference in the diagnosis of HSIL+ compared to LEEP in all patients (p<0.001). In age subgroup analyses, age groups <35 years and 35-50 years showed good agreement with the entire data set (p=0.496 and p=0.406, respectively), while age group ≥50 years did not (p=0.036).
conclusionA significant pathologic discrepancy was observed between CDB and LEEP results in women with cytologic HSILs. The diagnostic inaccuracy of CDB increased in those ≥50 years of age.
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