ArticleImmunity, inflammation and disease2020
Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-κB inflammatory signaling pathway in human skin cells.
Article in Immunity, inflammation and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
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- Whole blood transcriptomics analysis of Indonesians reveals translocated and pathogenic microbiota in blood.PloS one · 2025Article
- The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis.International journal of chronic obstructive pulmonary disease · 2025Article
- Preliminary insights into the gut microbiota of patients with rheumatoid arthritis in Vietnam.PeerJ · 2025Article
- From Soil to Surface: Exploring the Impact of Green Infrastructure on Microbial Communities in the Built Environment.Journal of genomics · 2025Article
- Decoding the impact of ageing and environment stressors on skin cell communication.Biogerontology · 2024Review
- Sanitization of hydroponic farming facilities in Singapore: what, why, and how.Applied and environmental microbiology · 2024Article
- Changes functional prediction of ear canal flora in chronic bacterial otitis externa.Frontiers in cellular and infection microbiology · 2024Article
- Remodeling of Paranasal Sinuses Mucosa Functions in Response to Biofilm-Induced Inflammation.Journal of inflammation research · 2024Review
- Microbiological effect of topically appliedFrontiers in veterinary science · 2024Article
- Genomic characterization of themSystems · 2023Article
- The Human Ocular Surface Microbiome and Its Associations with the Tear Proteome in Dry Eye Disease.International journal of molecular sciences · 2023Article
- A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae.PLoS genetics · 2023Article
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
introductionCorynebacterium tuberculostearicum (C. t.) is a ubiquitous bacterium that colonizes human skin. In contrast to other members of the genus Corynebacterium, such as toxigenic Corynebacterium diphtheriae or the opportunistic pathogen Corynebacterium jeikeium, several studies suggest that C. t. may play a role in skin health and disease. However, the mechanisms underlying these effects remain poorly understood.
methodsTo investigate whether C. t. induces inflammatory pathways in primary human epidermal keratinocytes (HEKs) and human cutaneous squamous carcinoma cells (SCCs), cell culture, reverse transcription-polymerase chain reaction (PCR), enzyme-linked immunosorbent assay, immunofluorescence microscopy, Western blot, chromatin immunoprecipitation-PCR, small interfering RNA knockdown and luciferase reporter expression system were used.
resultsHerein, we demonstrate that C. t. upregulates the messenger RNA (mRNA) and protein levels of inflammatory mediators in two human skin cell lines, HEKs and SCCs. We further show activation of the canonical nuclear factor-κB (NF-κB) pathway in response to C. t. infection, including phosphorylation of the inhibitor of κB (IκB), the nuclear translocation of NF-κB subunit (NF-κB-P
conclusionOur results offer a mechanistic model for C. t.-induced inflammation in human keratinocytes via TLR
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.