Evidence map›Paper›PMID 31912442›Full record

ArticleMolecular neurobiology2020

Elevated Type 1 Metabotropic Glutamate Receptor Availability in a Mouse Model of Huntington's Disease: a Longitudinal PET Study.

Daniele Bertoglio, Jeroen Verhaeghe, Špela Korat, Alan Miranda, Klaudia Cybulska, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez, Mette Skinbjerg and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Altered Excitation-Inhibition Balance and mGluRInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. A Review of Molecular Imaging of Glutamate Receptors.Molecules (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Daniele BertoglioMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.ORCID https://orcid.org/0000-0003-4205-5432
Jeroen VerhaegheMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Špela KoratMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Alan MirandaMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Klaudia CybulskaMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Leonie WyffelsMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Sigrid StroobantsMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Ladislav MrzljakCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Celia DominguezCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Mette SkinbjergCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Longbin LiuCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Ignacio Munoz-SanjuanCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Steven StaelensMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium. steven.staelens@uantwerpen.be.
University of Antwerp · BECHDI Foundation · US

Funding

FWO 11W2518N
6 · The paper itself

Abstract

Impairment of group I metabotropic glutamate receptors (mGluRs) results in altered glutamate signalling, which is associated with several neurological disorders including Huntington's Disease (HD), an autosomal neurodegenerative disease. In this study, we assessed in vivo pathological changes in mGluR1 availability in the Q175DN mouse model of HD using longitudinal positron emission tomography (PET) imaging with the radioligand [

Indexed as

Positron-Emission TomographyAnimalsBenzamidesDisease Models, AnimalHuntington DiseaseMice, Inbred C57BLReceptors, Metabotropic GlutamateThiazoles4-fluoroethoxy-N-(4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methylbenzamideBenzamidesmetabotropic glutamate receptor type 1Receptors, Metabotropic GlutamateThiazoles[11C]ITDMBrain imagingGlutamatemGluR1Receptor

Identifiers

PMID31912442
PMCPMC7118044
OpenAlexW2999607299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.