ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020
Subcapsular orchiectomy versus total orchiectomy and LHRH analogue in the treatment of hormone-sensitive metastatic prostate cancer: a different perspective in evaluation of the psychosocial effects.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Pooled it
- Luteinizing hormone-releasing hormone agonists versus orchiectomy in the treatment of prostate cancer: A systematic review.Frontiers in endocrinology · 2023Pooled it
- Satisfaction and genital perception after orchiectomy for prostate cancer: does the technique matter? A randomized trial.International urology and nephrology · 2021Trial
- Metformin and Flutamide Combination Therapy's Efficacy and Safety in Prostate Cancer Cell Lines.Prostate cancer · 2026Article
- Late side effects of testicular cancer and treatment: a comprehensive review.Discover oncology · 2024Review
- The Lancet Commission on prostate cancer: planning for the surge in cases.Lancet (London, England) · 2024Review
- Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer.Cancer biology & medicine · 2024Observational
- Simple and Epididymal-Sparing Orchiectomy for Surgical Castration in Stage IV Prostate Cancer.Ochsner journal · 2024Article
- Significant financial differences of chemical and surgical androgen deprivation in a contemporary cohort.Translational andrology and urology · 2022Article
- Psychosocial Aspects of Living Long Term with Advanced Cancer and Ongoing Systemic Treatment: A Scoping Review.Cancers · 2022Article
- Quality of life in low-income men after surgical castration for metastatic prostate cancer.Urologic oncology · 2022Article
- What Is Your Choice for Androgen Deprivation Therapy in Metastatic Prostate Carcinoma: Surgical or Medical?Turkish journal of urology · 2022Article
- Psychological State and Decision Perceptions of Male and Female Cancer Patients on Fertility Preservation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Sexual dysfunction associated with prostate cancer treatment in Japanese men: a qualitative research.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates.Nanomaterials (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to compare total orchiectomy, subcapsular orchiectomy, and luteinizing hormone-releasing hormone (LHRH) analogue treatment in patients with hormone-sensitive metastatic prostate cancer in terms of efficacy of androgen deprivation treatment (ADT), patient satisfaction, health-related quality of life (HRQoL), development of phantom testis syndrome (PTS), and post-traumatic stress disorder (PTSD).
methodAmong 272 patients treated between July 2015 and January 2019, 189 patients were enrolled in this prospective, cohort study and the patients were divided into three groups: group I, bilateral total orchiectomy (n 66); group II, bilateral subcapsular orchiectomy (n 63); and group III, LHRH analogue treatment (n 60). The adequacy of ADT was routinely monitored every 3 months and clinical parameters were evaluated. After 6 to 36 months following ADT, questionnaires were used to evaluate PTS, PTSD, and HRQoL during outpatient visits. The patient satisfaction was questioned as yes/no.
resultsAdequate castration was provided with all three treatments, while the presence and frequency of PTS and severity of PTSD were lower, and patient satisfaction related to ADT and all components of HRQoL were better in patients undergoing subcapsular orchiectomy than those undergoing total orchiectomy. All findings except for PTS were similar in patients undergoing subcapsular orchiectomy and LHRH analogue treatment. In analysis of all patients, total incidence of PTS was 43.4% and PTSD was reported to be 48.7%. A strong relationship was found between PTSD and phantom testis pain (r 0.621, p < 0.001).
conclusionsSubcapsular orchiectomy has less psychosocial side effects than total orchiectomy and is similar to LHRH analogue treatment. It can be a reliable, cheaper, and fast-acting alternative to LHRH analogue treatment.
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