Evidence map›Paper›PMID 31912360›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Incidence of the adverse effects of androgen deprivation therapy for prostate cancer: a systematic literature review.

Kim Edmunds, Haitham Tuffaha, Daniel A Galvão, Paul Scuffham, Robert U Newton

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  3. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  15. Qualitative exploration of sexual dysfunction and associated coping strategies among Iranian prostate cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kim EdmundsCentre for Applied Health Economics, Griffith University, Nathan, QLD, Australia. k.edmunds@griffith.edu.au.ORCID https://orcid.org/0000-0001-7379-1294
Haitham TuffahaCentre for Applied Health Economics, Griffith University, Nathan, QLD, Australia.ORCID https://orcid.org/0000-0003-2993-3480
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.ORCID https://orcid.org/0000-0002-8209-2281
Paul ScuffhamCentre for Applied Health Economics, Griffith University, Nathan, QLD, Australia.ORCID https://orcid.org/0000-0001-5931-642X
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Griffith University · AUEdith Cowan University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAndrogen deprivation therapy (ADT) has broad application in the treatment of prostate cancer (PC) and is associated with numerous, debilitating adverse effects. Increasing use of ADT for PC, longer timeframe for treatment (increased uptake of PSA testing and earlier diagnosis), as well as improved survival and an ageing population, means patients can live for a considerable period of time on or after ADT, experiencing these adverse effects. A number of systematic reviews of adverse effects of ADT for PC exist; however, no single systematic review has previously examined the evidence for all adverse effects, including newer forms of ADT.

methodsA systematic review of existing systematic reviews of ADT for PC was conducted (2010-February 2019), as per Cochrane guidelines, to identify the highest level of risk/incidence evidence available, supplemented by evidence drawn from individual studies where no systematic review existed.

resultsIncidence data was generated for 19 adverse effect subgroups, classified according to the common terminology criteria for adverse events (CTCAE).

conclusionIncidence of adverse effects provides valuable information for future burden of disease studies. This information can better guide clinical management to reduce symptoms for patients and assist patients to make more informed decisions about their treatment, potentially improving disease outcomes. It also highlights the importance of supportive care for PC patients receiving ADT and their carers. For analysts conducting economic evaluations, the inclusion of adverse effects in PC decision analytic models can provide more comprehensive and accurate information for decision makers.

Indexed as

Androgen AntagonistsHumansIncidenceMaleMiddle AgedProstatic NeoplasmsAndrogen AntagonistsAdverse effectsAndrogen deprivation therapyIncidenceProstate cancer

Identifiers

PMID31912360
OpenAlexW2999772591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.