Evidence map›Paper›PMID 31912323›Full record

ArticleAMB Express2020

Synergistic renoprotective effects of sesame oil and erythropoietin on ischemic kidney injury after renal transplantation.

Liyu Ye, Fang Xiao, Jijun Xie, Lingling Feng, Zhangjun Tang, E Chen, Chuchu Chen, Bowen Xu, Ronghai Deng

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in AMB Express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Liyu YeSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Fang XiaoSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Jijun XieSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Lingling FengSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Zhangjun TangSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
E ChenSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Chuchu ChenSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Bowen XuSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Ronghai DengSecond District of Organ Transplant, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China. RoscoeHornftc@yahoo.com.
Sun Yat-sen University · CN

Funding

Natural Science Foundation of Guangdong Province 2016A030313190
6 · The paper itself

Abstract

In this study, we evaluated the combined therapeutic efficacy of erythropoietin (a hematopoietic hormone produced by the fetal liver and kidney in response to inflammation and apoptosis) and sesame oil (from Sesamum indicum L.) on ischemic kidney injury following kidney transplantation in a rat model. Rats were assigned to the following groups: sham, control, 1000 U/kg erythropoietin, 1 mL/kg sesame oil, 1000 U/kg erythropoietin + 1 mL/kg sesame oil, and positive control. We measured the levels of blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), lipid peroxidation, reactive oxygen species (ROS), reduced glutathione (GSH), antioxidant enzymes, and proinflammatory markers and performed renal histopathological evaluation. The combined erythropoietin and sesame oil treatment significantly reduced BUN, ALT, creatinine, lipid peroxidation, ROS, and proinflammatory markers and GSH and antioxidant enzyme levels. Histopathological examination showed that the combined erythropoietin and sesame oil treatment significantly reduced necrosis. Therefore, combined treatment of sesame oil and erythropoietin may represent an effective therapeutic approach against ischemic kidney injury after kidney transplantation.

Indexed as

ErythropoietinIschemic injuryOxidative stressRenal transplantationSesame oil

Identifiers

PMID31912323
PMCPMC6946783
OpenAlexW2999173911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.