Evidence map›Paper›PMID 31912264›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2020

Ectopic expression of the Stabilin2 gene triggered by an intracisternal A particle (IAP) element in DBA/2J strain of mice.

Nobuyo Maeda-Smithies, Sylvia Hiller, Sharlene Dong, Hyung-Suk Kim, Brian J Bennett, Yukako Kayashima

Open access · hybridAbstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Reduction ofFrontiers in cardiovascular medicine · 2022
    Article
  8. Article
  9. KRAB zinc finger protein diversification drives mammalian interindividual methylation variability.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nobuyo Maeda-SmithiesDepartment of Pathology and Laboratory Medicine, University of North Carolina At Chapel Hill, CB#7525, 701 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599-7525, USA.
Sylvia HillerDepartment of Pathology and Laboratory Medicine, University of North Carolina At Chapel Hill, CB#7525, 701 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599-7525, USA.
Sharlene DongDepartment of Pathology and Laboratory Medicine, University of North Carolina At Chapel Hill, CB#7525, 701 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599-7525, USA.
Hyung-Suk KimDepartment of Pathology and Laboratory Medicine, University of North Carolina At Chapel Hill, CB#7525, 701 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599-7525, USA.
Brian J BennettDepartment of Genetics, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
Yukako KayashimaDepartment of Pathology and Laboratory Medicine, University of North Carolina At Chapel Hill, CB#7525, 701 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599-7525, USA. yukaya@email.unc.edu.ORCID 0000-0003-3415-9135
University of North Carolina at Chapel Hill · US

Funding

MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
APOLIPOROTEIN GENES AND ATHEROGENESISR01HL042630 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1989 to 2017
$4.9M
APOLIPOPROTEIN GENES AND ATHEROGENESIS IN ANIMALSR37HL042630 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1998 to 2007
$3.4M
Systems Genetic Studies of TMAO regulation and AtherosclerosisR01HL128572 · NHLBI · U.S. AGRICULTURAL RESEARCH SERVICE · PI BENNETT, BRIAN JOSEPH · 2015 to 2019
$1.4M
NHLBI NIH HHS R01 HL042630NHLBI NIH HHS R01 HL049277NHLBI NIH HHS R01 HL128572NHLBI NIH HHS R37 HL042630
6 · The paper itself

Abstract

Stabilin2 (Stab2) encodes a large transmembrane protein which is predominantly expressed in the liver sinusoidal endothelial cells (LSECs) and functions as a scavenger receptor for various macromolecules including hyaluronans (HA). In DBA/2J mice, plasma HA concentration is ten times higher than in 129S6 or C57BL/6J mice, and this phenotype is genetically linked to the Stab2 locus. Stab2 mRNA in the LSECs was significantly lower in DBA/2J than in 129S6, leading to reduced STAB2 proteins in the DBA/2J LSECs. We found a retrovirus-derived transposable element, intracisternal A particle (IAP), in the promoter region of Stab2

Indexed as

Ectopic Gene ExpressionAllelesAnimalsCell Adhesion Molecules, NeuronalChromosomes, MammalianDNA MethylationEndothelial CellsGenes, Intracisternal A-ParticleGenetic VariationHEK293 CellsHumansHyaluronic AcidLiverMiceMice, 129 StrainMice, Inbred C57BLCell Adhesion Molecules, NeuronalHyaluronic AcidStab2 protein, mouse

Identifiers

PMID31912264
PMCPMC7060167
OpenAlexW3000596614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.