Evidence map›Paper›PMID 31912192›Full record

ArticlePsychopharmacology2020

Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration.

Glenn W Stevenson, Denise Giuvelis, James Cormier, Katherine Cone, Phillip Atherton, Rebecca Krivitsky, Emily Warner, Brooke St Laurent, Julio Dutra, Jean M Bidlack and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Glenn W StevensonDepartment of Psychology, University of New England, Biddeford, ME, 04005, USA. gstevenson@une.edu.ORCID http://orcid.org/0000-0002-5869-3714
Denise GiuvelisDepartment of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005, USA.
James CormierDepartment of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005, USA.
Katherine ConeDepartment of Psychology, University of New England, Biddeford, ME, 04005, USA.
Phillip AthertonDepartment of Psychology, University of New England, Biddeford, ME, 04005, USA.
Rebecca KrivitskyDepartment of Psychology, University of New England, Biddeford, ME, 04005, USA.
Emily WarnerDepartment of Psychology, University of New England, Biddeford, ME, 04005, USA.
Brooke St LaurentDepartment of Psychology, University of New England, Biddeford, ME, 04005, USA.
Julio DutraDepartment of Psychology, University of New England, Biddeford, ME, 04005, USA.
Jean M BidlackDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Lajos SzabòDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA.
Robin PoltDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA.
Edward J BilskyCenter for Excellence in the Neurosciences, University of New England, Biddeford, ME, USA.
University of New England · USNew England College · USUniversity of Arizona · USUniversity of Rochester · US

Funding

Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9M
Measurement of pain-suppressed behaviors in rodent models of chronic painR15AR054975 · NIAMS · UNIVERSITY OF NEW ENGLAND · PI STEVENSON, GLENN W. · 2007 to 2014
$579k
Novel Glycosylated Delta Opioid Receptor Agonists for Chronic Inflammatory PainR43DA026653 · NIDA · BIOUSIAN BIOSYSTEMS, INC. (BBI) · PI KITSOS, CHRISTINE M · 2009 to 2009
$200k
NIAMS NIH HHS R15 AR054975NIDA NIH HHS R43 DA026653NIGMS NIH HHS P20 GM103643NIH HHS AR054975NIH HHS DA026653-01A1
6 · The paper itself

Abstract

RATIONALE AND

objectivesThe present study characterized the behavioral pharmacology of a novel, mixed-action delta-selective (78:1) opioid receptor agonist, BBI-11008. This glycopeptide drug candidate was tested in assays assessing antinociception (acute, inflammatory, and neuropathic pain-like conditions) and side-effect endpoints (respiratory depression and drug self-administration).

resultsBBI-11008 had a 78-fold greater affinity for the delta opioid receptor than the mu receptor, and there was no binding to the kappa opioid receptor. BBI-11008 (3.2-100; 10-32 mg kg

conclusionsThese results suggest that the glycopeptide drug candidate possesses broad-spectrum antinociceptive and anti-allodynic activity across a range of pain-like conditions. Relative to morphine or fentanyl, the profile for BBI-11008 in the respiration and drug self-administration assays suggests that BBI-11008 may have less pronounced deleterious side effects. Continued assessment of this compound is warranted.

Indexed as

Analgesics, OpioidAnimalsCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugHumansInflammationMaleMiceMorphineNeuralgiaPain MeasurementRatsRats, Sprague-DawleyReceptors, Opioid, deltaAnalgesics, OpioidMorphineReceptors, Opioid, deltaReceptors, Opioid, kappaReceptors, Opioid, muAntiallodyniaAntinociceptionDelta/mu opioid agonistDelta opioid receptorDrug self-administrationGI transitGlycopeptideMiceRatsRespiratory depression

Identifiers

PMID31912192
PMCPMC8106974
OpenAlexW2998220725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.