ArticleScience advances2020
Control of protein function through oxidation and reduction of persulfidated states.
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Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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104citing papers in PubMed
14.6field-weighted citation impact, top 1% of its field
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Who cites it
104 citing papers in PubMed, 199 citations in OpenAlex.
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- MAPK Inhibitor-Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities.Cancer science · 2026Review
- Mechanistic insights into TXNDC17-mediated ferroptosis suppression in glioblastoma progression.Biology direct · 2026Article
- Redox Network Failure in Chronic Kidney Disease: Hydrogen Sulfide Deficiency, Reactive Sulfur Species Dysregulation and the Uremic Toxin-AhR-Mitochondrial Axis.Antioxidants (Basel, Switzerland) · 2026Review
- Endogenous Sulfane Sulfur Mediates the Oxidative Stress Response Process inAntioxidants (Basel, Switzerland) · 2026Article
- A labile sulfur ligand in a three-cysteine-coordinated [2Fe-2S] cluster mediates sulfide sensing in NreB.Nature communications · 2026Article
- Context‑dependent targeting of thioredoxin reductase 1 in cancer: a mechanistic review.Magyar onkologia · 2026Review
- Cystine C-S bond cleavage fuels cysteine production under disulfide reductase deficiency.Nature chemical biology · 2026Article
- Transcriptomic and proteomic evidence for noncanonical hydrogen sulfide metabolism and immune dysregulation in Down Syndrome.Scientific reports · 2026Article
- Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides.Redox biology · 2026Article
- Intracellular enzymatic reducing systems control receptor tyrosine kinase signaling via PTP1B.Science advances · 2026Article
- Protein oxidation in crowded environments.The Biochemical journal · 2026Review
- Multifaceted roles for persulfide species in redox chemical biology.Nature chemical biology · 2026Review
- A Dinuclear Iron(II) Persulfide Complex Reacts with OJournal of the American Chemical Society · 2026Article
- The Role of Ferroptosis in Diabetes Pathogenesis: Therapeutic Implications of Hydrogen Sulfide and Its Reactive Metabolites.Antioxidants (Basel, Switzerland) · 2026Review
- Moonlighting Functions of Mammalian Peroxiredoxins in Cellular Signaling.Antioxidants (Basel, Switzerland) · 2026Review
- Pathophysiology of reactive oxygen species (ROS).Archives of toxicology · 2026Review
- Article
- Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structural insights into the Urm1-Uba4 pathway and its biological roles.Essays in biochemistry · 2025Review
44 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 7 institutions in 5 countries.
É DókaDepartment of Molecular Immunology and Toxicology, National Institute of Oncology, 1122 Budapest, Hungary.ORCID 0000-0002-7966-2431
T IdaDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan.ORCID 0000-0002-4443-6127
M DagnellDepartment of Medical Biochemistry and Biophysics, Division of Biochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0002-5925-6794
Y AbikoEnvironmental Biology Section, Faculty of Medicine, University of Tsukuba, 305-8575 Tsukuba, Japan.ORCID 0000-0002-0608-5135
N C LuongEnvironmental Biology Section, Faculty of Medicine, University of Tsukuba, 305-8575 Tsukuba, Japan.ORCID 0000-0001-6625-9785
N BalogDepartment of Molecular Immunology and Toxicology, National Institute of Oncology, 1122 Budapest, Hungary.
T TakataDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan.ORCID 0000-0002-6691-2569
B EspinosaDepartment of Medical Biochemistry and Biophysics, Division of Biochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
A NishimuraDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan.
Q ChengDepartment of Medical Biochemistry and Biophysics, Division of Biochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0002-3170-9333
Y FunatoDepartment of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
H MikiDepartment of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
J M FukutoDepartment of Chemistry, Sonoma State University, Rohnert Park, Sonoma, CA 94928, USA.
J R PriggeDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
E E SchmidtDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
E S J ArnérDepartment of Medical Biochemistry and Biophysics, Division of Biochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0002-4807-6114
Y KumagaiEnvironmental Biology Section, Faculty of Medicine, University of Tsukuba, 305-8575 Tsukuba, Japan.ORCID 0000-0003-4523-8234
T AkaikeDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan.ORCID 0000-0002-0623-1710
P NagyDepartment of Molecular Immunology and Toxicology, National Institute of Oncology, 1122 Budapest, Hungary.ORCID 0000-0003-3393-235X
Karolinska Institutet · SETohoku University · JPNational Institute of Oncology · HUUniversity of Tsukuba · JPMontana State University · USThe University of Osaka · JPSonoma State University · US
Funding
Pilot Grants ProgramP30GM110732 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI QUINN, MARK T · 2014 to 2018
$5.4MMechanisms of arsenic detoxification by the human microbiomeR01CA215784 · NCI · MONTANA STATE UNIVERSITY - BOZEMAN · PI Seth T Walk, Qian Wang · 2017 to 2026
$2.7MImpact of hepatocyte lineage life history dynamics on liver homeostasis in the agR01AG040020 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI GEDEON, TOMAS, SCHMIDT, EDWARD E · 2011 to 2015
$1.5MMetabolic basis of the NADPH-independent disulfide reductase system in mouse liverR01DK123738 · NIDDK · MONTANA STATE UNIVERSITY - BOZEMAN · PI DENICOLA, GINA MARIE, SCHMIDT, EDWARD E · 2020 to 2022
$1.3MMetabolic basis of the NADPH-independent disulfide reductase system in mouse liverR56DK123738 · NIDDK · MONTANA STATE UNIVERSITY - BOZEMAN · PI DENICOLA, GINA MARIE, SCHMIDT, EDWARD E · 2019 to 2019
$464kHepatocyte-targeted somatic-cell genetic complementation in miceR21OD026444 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI SCHMIDT, EDWARD E · 2019 to 2020
$396kRedox regulation in the hepatostatR21AG055022 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI ARNER, ELIAS S.J., NAGY, PETER · 2016 to 2017
$382kNCI NIH HHS R01 CA215784NIA NIH HHS R01 AG040020NIA NIH HHS R21 AG055022NIDDK NIH HHS R01 DK123738NIDDK NIH HHS R56 DK123738NIGMS NIH HHS P30 GM110732NIH HHS R21 OD026444
Abstract
Irreversible oxidation of Cys residues to sulfinic/sulfonic forms typically impairs protein function. We found that persulfidation (CysSSH) protects Cys from irreversible oxidative loss of function by the formation of CysSSO
Indexed as
AnimalsCysteineEpidermal Growth FactorHomeodomain ProteinsHSP90 Heat-Shock ProteinsHumansKelch-Like ECH-Associated Protein 1MiceOxidation-ReductionProtein Tyrosine Phosphatase, Non-Receptor Type 1PTEN PhosphohydrolaseSeleniumSignal TransductionSulfidesThioredoxin Reductase 1ThioredoxinsCysteineEpidermal Growth FactorHomeodomain ProteinsHSP90 Heat-Shock ProteinsKelch-Like ECH-Associated Protein 1persulfidesProtein Tyrosine Phosphatase, Non-Receptor Type 1PRRX2 protein, humanPTEN PhosphohydrolasePTPN1 protein, humanSeleniumSulfidesThioredoxin Reductase 1ThioredoxinsTXNDC17 protein, humanTxnrd1 protein, mouse
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