Evidence map›Paper›PMID 31911890›Full record

ArticleNanotheranostics2020

Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers.

Nikhil Pandey, Jyothi U Menon, Masaya Takahashi, Jer-Tsong Hsieh, Jian Yang, Kytai T Nguyen, Aniket S Wadajkar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotheranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Near-infrared temperature-switchable fluorescence nanoparticles.Quantitative imaging in medicine and surgery · 2021
    Article
  14. Review
  15. DNA Nanostructures and DNA-Functionalized Nanoparticles for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nikhil PandeyDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Jyothi U MenonDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Masaya TakahashiDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jer-Tsong HsiehDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jian YangDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Kytai T NguyenDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Aniket S WadajkarDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
The University of Texas Southwestern Medical Center · USPennsylvania State University · USUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theranostic systems capable of delivering imaging and therapeutic agents at a specific target are the focus of intense research efforts in drug delivery. To overcome non-degradability and toxicity concerns of conventional theranostic systems, we formulated a novel thermo-responsive fluorescent polymer (TFP) and conjugated it on the surface of iron oxide magnetic nanoparticles (MNPs) for imaging and therapeutic applications in solid tumors.

methodsTFP-MNPs were synthesized by copolymerizing poly(

resultsTFP-MNPs of ~135 nm diameter and -31 mV ζ potential maintained colloidal stability and superparamagnetic properties. The TFP shell was thermo-responsive, fluorescent, degradable, and released doxorubicin in response to temperature changes.

conclusionThese results indicate the potential of TFP-MNPs as multifunctional theranostic nanoparticles for various biological applications, including solid cancer management.

Indexed as

Antineoplastic AgentsFluorescent DyesMagnetite NanoparticlesAnimalsCell LineCell Line, TumorHumansMaleMiceMice, SCIDMultimodal ImagingNeoplasms, ExperimentalTemperatureTheranostic NanomedicineXenograft Model Antitumor AssaysAntineoplastic AgentsFluorescent DyesMagnetite Nanoparticlesmagnetic nanoparticlesphotoluminescent polymerssolid tumorstheranostic systemsthermo-responsive polymers

Identifiers

PMID31911890
PMCPMC6940202
OpenAlexW2992408432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.