Evidence map›Paper›PMID 31911677›Full record

ArticleNature genetics2020

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman and 336 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Association Between theFrontiers in genetics · 2022
    Pooled it
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

346 authors.

Laura FachalCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Hugues Aschard *Centre de Bioinformatique Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-7554-6783
Jonathan Beesley *Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Daniel R BarnesCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3781-7570
Jamie AllenCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Siddhartha KarCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Karen A PooleyCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4591-1214
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7065-1237
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Penny SoucyGenomics Center, Centre Hospitalier Universitaire de Québec, Université Laval Research Center, Québec City, Québec, Canada.
Audrey LemaçonGenomics Center, Centre Hospitalier Universitaire de Québec, Université Laval Research Center, Québec City, Québec, Canada.ORCID http://orcid.org/0000-0002-1817-7029
Michael LushCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jonathan P TyrerCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Maya GhoussainiCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Mahdi Moradi MarjanehDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Xia JiangProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Simona AgataImmunology and Molecular Oncology Unit, Veneto Institute of Oncology (IOV), IRCCS, Padua, Italy.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
M Rosario AlonsoHuman Genotyping-CEGEN Unit, Human Cancer Genetic Program, Spanish National Cancer Research Centre, Madrid, Spain.
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-4226-6435
Hoda Anton-CulverDepartment of Epidemiology, Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, CA, USA.
Natalia N AntonenkovaN.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Adalgeir ArasonDepartment of Pathology, Landspitali University Hospital, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-0480-886X
Volker ArndtDivision of Clinical Epidemiology and Aging Research (C070), German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9320-8684
Kristan J AronsonDepartment of Public Health Sciences and Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.
Banu K ArunDepartment of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bernd AuberInstitute of Human Genetics, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0003-1880-291X
Paul L AuerCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jacopo AzzolliniUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0000-0002-9364-9778
Judith BalmañaHigh Risk and Cancer Prevention Group, Vall Hebron Institute of Oncology, Barcelona, Spain.
Rosa B BarkardottirDepartment of Pathology, Landspitali University Hospital, Reykjavik, Iceland.
Daniel BarrowdaleCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Alicia Beeghly-FadielDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Javier BenitezCentro de Investigación en Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
Marina BermishevaInstitute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
Katarzyna BiałkowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Amie M BlancoCancer Genetics and Prevention Program, University of California, San Francisco, San Francisco, CA, USA.
Carl BlomqvistDepartment of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
William BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Natalia V BogdanovaN.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Stig E BojesenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.ORCID http://orcid.org/0000-0002-4061-4133
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Bernardo BonanniDivision of Cancer Prevention and Genetics, European Institute of Oncology (IEO), IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0003-3589-2128
Ake BorgDepartment of Oncology, Lund University and Skåne University Hospital, Lund, Sweden.
Kristin BosseInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.ORCID http://orcid.org/0000-0001-7531-2736
Hermann BrennerDivision of Clinical Epidemiology and Aging Research (C070), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ignacio BricenoInstitute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
Ian W BrockSheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Angela Brooks-WilsonGenome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Thomas BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
Barbara BurwinkelMolecular Epidemiology Group (C080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Trinidad CaldésMolecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Maria A CaligoSOD Genetica Molecolare, University Hospital, Pisa, Italy.
Nicola J CampDepartment of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA.
Ian CampbellResearch Department, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-7773-4155
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jason S CarrollCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3643-0080
Brian D CarterBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Jose E CastelaoOncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.
Jocelyne ChiquetteAxe Oncologie, Centre de Recherche, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, Québec, Canada.
Hans ChristiansenDepartment of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
Kathleen B M ClaesCentre for Medical Genetics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0003-0841-7372
Christine L ClarkeWestmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
GEMO Study Collaborators
EMBRACE Collaborators
J Margriet ColléeDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9272-9346
Sten CornelissenDivision of Molecular Pathology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Angela CoxSheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
Cezary CybulskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
Miguel de la HoyaMolecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Peter DevileeDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-8023-2009
Orland DiezOncogenetics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Gillian S DiteCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Susan M DomchekBasser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-9458-0282
Isabel Dos-Santos-SilvaDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Arnaud DroitGenomics Center, Centre Hospitalier Universitaire de Québec, Université Laval Research Center, Québec City, Québec, Canada.
Stéphane DuboisGenomics Center, Centre Hospitalier Universitaire de Québec, Université Laval Research Center, Québec City, Québec, Canada.
Martine DumontGenomics Center, Centre Hospitalier Universitaire de Québec, Université Laval Research Center, Québec City, Québec, Canada.
Mercedes DuranCáncer Hereditario, Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid Centro Superior de Investigaciones Científicas (UVA-CSIC), Valladolid, Spain.
Lorraine DurcanSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Miriam DwekSchool of Life Sciences, University of Westminster, London, UK.ORCID http://orcid.org/0000-0001-7184-2932
Diana M EcclesFaculty of Medicine, University of Southampton, Southampton, UK.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
D Gareth EvansDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Peter A FaschingDavid Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Olivia FletcherBreast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-9387-7116
Giuseppe FlorisLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2391-5425
Henrik FlygerDepartment of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
William D FoulkesProgram in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Québec, Canada.ORCID http://orcid.org/0000-0001-7427-4651
Eitan FriedmanThe Suzanne Levy-Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
Lin FritschiSchool of Public Health, Curtin University, Perth, Western Australia, Australia.
Debra FrostCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Marike GabrielsonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
Gaetana GambinoSOD Genetica Molecolare, University Hospital, Pisa, Italy.
Patricia A GanzSchools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, Los Angeles, CA, USA.
Susan M GapsturBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Judy GarberCancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA.
José A García-SáenzMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.ORCID http://orcid.org/0000-0001-6880-0301
Mia M GaudetBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Vassilios GeorgouliasDepartment of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Gord GlendonFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA.
Mark S GoldbergDepartment of Medicine, McGill University, Montréal, Québec, Canada.
David E GoldgarDepartment of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
Anna González-NeiraHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Maria Grazia TibilettiU.O. Anatomia Patologica Ospedale di Circolo, ASST Settelaghi, Varese, Italy.
Mark H GreeneClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1852-9239
Mervi GripDepartment of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anne GrundyCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montréal, Québec, Canada.
Pascal GuénelCancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Paris, France.ORCID http://orcid.org/0000-0002-8359-518X
Eric HahnenCenter for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Niclas HåkanssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Patricia A HarringtonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Jaana M HartikainenTranslational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Wei HeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Catherine S HealeyCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Bernadette A M Heemskerk-GerritsenDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9724-6693
Jane HeyworthSchool of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.
Peter HillemannsGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Frans B L HogervorstFamily Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Antoinette HollestelleDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1166-1966
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Anthony HowellDivision of Cancer Sciences, University of Manchester, Manchester, UK.
Guanmengqian HuangMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Peter J HulickCenter for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-8397-4078
Evgeny N ImyanitovN.N. Petrov Institute of Oncology, St. Petersburg, Russia.
KConFab Investigators
HEBON Investigators
ABCTB Investigators
Claudine IsaacsLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Agnes JagerDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Milena JakimovskaResearch Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Republic of North Macedonia.ORCID http://orcid.org/0000-0002-1506-0669
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.ORCID http://orcid.org/0000-0002-5650-0501
Paul A JamesSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-4361-4657
Ramunas JanaviciusHematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.
Rachel C JankowitzDepartment of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Esther M JohnDepartment of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Nichola JohnsonBreast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Michael E JonesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-7479-3451
Arja Jukkola-VuorinenDepartment of Oncology, Tampere University Hospital, Tampere University and Tampere Cancer Center, Tampere, Finland.
Audrey JungDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daehee KangDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Pooja Middha KapoorDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5503-8215
Beth Y KarlanDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA.
Renske KeemanDivision of Molecular Pathology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-5452-9933
Michael J KerinSurgery, School of Medicine, National University of Ireland, Galway, Ireland.
Elza KhusnutdinovaInstitute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
Johanna I KiiskiDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Judy KirkFamilial Cancer Service, Weatmead Hospital, Sydney, New South Wales, Australia.
Cari M KitaharaRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Yon-Dschun KoDepartment of Internal Medicine, Evangelische Kliniken Bonn, Johanniter Krankenhaus, Bonn, Germany.
Irene KonstantopoulouMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.ORCID http://orcid.org/0000-0002-0470-0309
Veli-Matti KosmaTranslational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Katerina Kubelka-SabitDepartment of Histopathology and Cytology, Clinical Hospital 'Acibadem Sistina', Skopje, Republic of North Macedonia.
Ava KwongHong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.
Kyriacos KyriacouDepartment of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Yael LaitmanThe Suzanne Levy-Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
Diether LambrechtsVIB Center for Cancer Biology, VIB, Leuven, Belgium.
Eunjung LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Goska LeslieCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5756-6222
Jenny LesterDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA.
Fabienne LesueurInstitut Curie, Paris, France.ORCID http://orcid.org/0000-0001-7404-4549
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Wing-Yee LoDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Artitaya LophatananonDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Jennifer T LoudClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jan LubińskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Robert J MacInnisCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Tom MaishmanSouthampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Enes MakalicCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Arto MannermaaTranslational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Mehdi ManoochehriMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Siranoush ManoukianUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Sara MargolinDepartment of Oncology, Södersjukhuset, Stockholm, Sweden.
Maria Elena MartinezMoores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Tabea MaurerCancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dimitrios MavroudisDepartment of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece.
Rebecca MayesCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Lesley McGuffogCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Catriona McLeanAnatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-0302-5727
Noura MebiroukInstitut Curie, Paris, France.
Alfons MeindlDepartment of Gynecology and Obstetrics, University of Munich, Munich, Germany.
Austin MillerNRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA.ORCID http://orcid.org/0000-0001-9739-8462
Nicola MillerSurgery, School of Medicine, National University of Ireland, Galway, Ireland.
Marco MontagnaImmunology and Molecular Oncology Unit, Veneto Institute of Oncology (IOV), IRCCS, Padua, Italy.
Fernando MorenoMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-6429-988X
Anna Marie MulliganDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Victor M Muñoz-GarzonRadiation Oncology, Hospital Meixoeiro-XXI de Vigo, Vigo, Spain.
Taru A MuranenDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5895-1808
Steven A NarodWomen's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura University, Holy Makkah, Saudi Arabia.
Katherine L NathansonBasser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6740-0901
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0916-2976
Patrick NevenLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Finn C NielsenCenter for Genomic Medicine at Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Liene Nikitina-ZakeLatvian Biomedical Research and Study Centre, Riga, Latvia.
Aaron NormanDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Kenneth OffitClinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Edith OlahDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9936-1599
Håkan OlssonDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
Nick OrrCentre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0003-2866-942X
Ana OsorioCentro de Investigación en Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
V Shane PankratzUniversity of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0002-3742-040X
Janos PappDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Tjoung-Won Park-SimonGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Michael T ParsonsDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-3242-8477
James PaulCancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-7367-5816
Inge Sokilde PedersenMolecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.
Bernard PeisselUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Beth PeshkinLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.ORCID http://orcid.org/0000-0002-2997-4701
Paolo PeterlongoGenome Diagnostics Program, IFOM-the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.ORCID http://orcid.org/0000-0001-6951-6855
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-1685-8912
Dijana Plaseska-KaranfilskaResearch Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Republic of North Macedonia.ORCID http://orcid.org/0000-0001-8877-2416
Karolina PrajzendancDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Ross PrenticeCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nadege PresneauSchool of Life Sciences, University of Westminster, London, UK.
Darya ProkofyevaDepartment of Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa, Russia.
Miquel Angel PujanaProCURE, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0002-2449-0521
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.ORCID http://orcid.org/0000-0001-6298-4111
Susan J RamusSchool of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Johanna RantalaClinical Genetics, Karolinska Institutet, Stockholm, Sweden.
Rohini Rau-MurthyClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gad RennertClalit National Israeli Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.ORCID http://orcid.org/0000-0002-8512-068X
Harvey A RischChronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Mark RobsonClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3109-1692
Atocha RomeroMedical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.ORCID http://orcid.org/0000-0002-1634-7397
Maria RossingCenter for Genomic Medicine at Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Emmanouil SaloustrosDepartment of Oncology, University Hospital of Larissa, Larissa, Greece.ORCID http://orcid.org/0000-0002-0485-0120
Estela Sánchez-HerreroMedical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Marta SantamariñaCentro de Investigación en Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
Christobel SaundersSchool of Medicine, University of Western Australia, Perth, Western Australia, Australia.
Elinor J SawyerResearch Oncology, Guy's Hospital, King's College London, London, UK.
Maren T ScheunerCancer Genetics and Prevention Program, University of California, San Francisco, San Francisco, CA, USA.
Daniel F SchmidtCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Rita K SchmutzlerCenter for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Andreas SchneeweissMolecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research (C070), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Peter SchürmannGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Christopher ScottDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-1340-0647
Rodney J ScottDivision of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0001-7724-3404
Leigha SenterClinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Caroline M SeynaeveDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Priyanka SharmaDepartment of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, KS, USA.
Chen-Yang ShenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Christian F SingerDepartment of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Thomas P SlavinClinical Cancer Genomics, City of Hope, Duarte, CA, USA.
Snezhana SmichkoskaUniversity Clinic of Radiotherapy and Oncology, Medical Faculty, Ss. Cyril and Methodius University in Skopje, Skopje, Republic of North Macedonia.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
John J SpinelliPopulation Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-1337-7897
Jennifer StoneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-5077-0124
Dominique Stoppa-LyonnetDepartment of Tumour Biology, INSERM U830, Paris, France.
Christian SutterInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4051-5888
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Rulla M TamimiProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Yen Yen TanDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-1063-5352
William J TapperFaculty of Medicine, University of Southampton, Southampton, UK.
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal.ORCID http://orcid.org/0000-0002-4896-5982
Maria TengströmTranslational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Soo Hwang TeoBreast Cancer Research Programme, Cancer Research Malaysia, Kuala Lumpur, Malaysia.
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Alex TeuléHereditary Cancer Program, ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC, Barcelona, Spain.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odence, Denmark.
Darcy L ThullDepartment of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Marc TischkowitzProgram in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Québec, Canada.
Amanda E TolandDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-0271-1792
Rob A E M TollenaarDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Ian TomlinsonInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-3037-1470
Diana TorresInstitute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
Gabriela Torres-MejíaCenter for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Melissa A TroesterDepartment of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thérèse TruongCancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Paris, France.
Nadine TungDepartment of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Maria TzardiDepartment of Pathology, University Hospital of Heraklion, Heraklion, Greece.
Hans-Ulrich UlmerFrauenklinik der Stadtklinik Baden-Baden, Baden-Baden, Germany.
Celine M VachonDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Christi J van AsperenDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Lizet E van der KolkFamily Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Elizabeth J van RensburgDepartment of Genetics, University of Pretoria, Pretoria, South Africa.
Ana VegaFundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain.
Alessandra VielDivision of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.ORCID http://orcid.org/0000-0003-2804-0840
Joseph VijaiClinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7933-151X
Maartje J VogelFamily Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Barbara WappenschmidtCenter for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Clarice R WeinbergBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA.
Jeffrey N WeitzelClinical Cancer Genomics, City of Hope, Duarte, CA, USA.
Camilla WendtDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Hans WildiersLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7387-6845
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Drakoulis YannoukakosMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.ORCID http://orcid.org/0000-0001-7509-3510
Yan ZhangDivision of Clinical Epidemiology and Aging Research (C070), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
David HunterNuffield Department of Population Health, University of Oxford, Oxford, UK.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8494-732X
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Marjanka K SchmidtDivision of Molecular Pathology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2228-429X
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-5764-7268
Vessela N KristensenDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway.
Juliet D FrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Stacey L EdwardsDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7428-4139
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec, Université Laval Research Center, Québec City, Québec, Canada.ORCID http://orcid.org/0000-0001-6906-3390
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2444-3247
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. pkraft@hsph.harvard.edu.ORCID http://orcid.org/0000-0002-4472-8103
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. amd24@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0001-6651-7166

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Steven Allan Soper · 2019 to 2026
$21.5M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Statistical methods for studies of rare variantsR01MH101244 · NIMH · HARVARD MEDICAL SCHOOL · PI Benjamin Michael Neale, ALKES L PRICE · 2013 to 2026
$9.4M
The Two Sister StudyZIAES102245 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WEINBERG, CLARICE · 2009 to 2025
$8.6M
Genetic Susceptibility And The Environment In Cancer RiskZIAES049033 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$7.7M
Network Lead Academic Participating Site Grant from the Roswell Park Cancer InstituteUG1CA233191 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI LELE, SHASHIKANT, LEVINE, ELLIS G · 2019 to 2025
$3.1M
Cancer Research UK 10118Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK 19187Cancer Research UK 20411Cancer Research UK 20861Cancer Research UK 23382Cancer Research UK 26886Cancer Research UK 29186Cancer Research UK A10118Cancer Research UK A10710Cancer Research UK A16563Medical Research Council MC_PC_14105NCATS NIH HHS UL1 TR001863NCI NIH HHS K08 CA234394NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA204954NCI NIH HHS U19 CA148065NCI NIH HHS UG1 CA233191NIEHS NIH HHS P30 ES010126NIGMS NIH HHS P20 GM130423NIMH NIH HHS R01 MH101244Wellcome Trust 203477/Z/16/Z
6 · The paper itself

Abstract

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideQuantitative Trait LociBayes TheoremBiomarkers, TumorBreast NeoplasmsChromosome MappingFemaleHumansLinkage DisequilibriumRegulatory Sequences, Nucleic AcidRisk FactorsBiomarkers, Tumor

Identifiers

PMID31911677
PMCPMC6974400

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