ArticleNature communications2020
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Effects of serratus anterior plane block and thoracic paravertebral nerve block on analgesia, immune function and serum tumor markers in patients after thoracoscopic radical resection of lung cancer.Nagoya journal of medical science · 2022Trial
- Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression.bioRxiv : the preprint server for biology · 2026Article
- Unique clinical features and transcriptomic profiling of carcinogenesis in patients with familial lung cancer in Yunnan Province, Wumeng mountains, China.Respiratory research · 2026Article
- Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction.Nature genetics · 2026Article
- Association of meteorological exposures with major cancer mortality in Minhang District, Shanghai: a time series study based on distributed lag non-linear models.Frontiers in public health · 2026Article
- Reply to Chaïbi and Tandjaoui-Lambiotte and to Young and Scott.American journal of respiratory and critical care medicine · 2025Article
- The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.Physiological reviews · 2025Review
- Identification of Candidate Lung Function-Related Plasma Proteins to Pinpoint Drug Targets for Common Pulmonary Diseases: A Comprehensive Multi-Omics Integration Analysis.Current issues in molecular biology · 2025Article
- The immune cells causative role in lung cancer: Mendelian randomization study.Discover oncology · 2024Article
- Roles of naïve CD4Journal of translational medicine · 2024Article
- Impaired lung function and lung cancer risk in 461 183 healthy individuals: a cohort study.BMJ open respiratory research · 2024Article
- Exploring the relationship between Treg-mediated risk in COPD and lung cancer through Mendelian randomization analysis and scRNA-seq data integration.BMC cancer · 2024Article
- Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk.Genome medicine · 2024Article
- Analyzing lung cancer risks in patients with impaired pulmonary function through characterization of gut microbiome and metabolites.BMC pulmonary medicine · 2024Article
- Silencing KLF6 Alleviates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction in Bronchial Epithelial Cells by SIRT4 Upregulation.International journal of chronic obstructive pulmonary disease · 2024Article
- Prediction of iodine-125 seed implantation efficacy in lung cancer using an enhanced CT-based nomogram model.PloS one · 2024Article
- The relationship of airflow limitation with lung squamous cell carcinoma: evidence from mendelian randomization analysis.Journal of cancer research and clinical oncology · 2023Article
- Localization Pattern of Dispatched Homolog 2 (DISP2) in the Central and Enteric Nervous System.Journal of molecular neuroscience : MN · 2023Article
- Article
Corrections and comments
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Authors and funding
51 authors at 20 institutions in 12 countries.
Linda KachuriDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Mattias JohanssonInternational Agency for Research on Cancer, Lyon, France.
Sara R RashkinDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5542-6891
Rebecca E GraffDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0316-8303
Yohan BosséInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada.ORCID http://orcid.org/0000-0002-3067-3711
Venkata ManemInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada.
Neil E CaporasoDivision of Cancer Epidemiology & Genetics, US NCI, Bethesda, MD, USA.
Maria Teresa LandiDivision of Cancer Epidemiology & Genetics, US NCI, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4507-329X
David C ChristianiDepartments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0301-0242
Paolo VineisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Geoffrey LiuPrincess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.
Ghislaine SceloInternational Agency for Research on Cancer, Lyon, France.
David ZaridzeRussian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.
Sanjay S SheteDepartment of Biostatistics, Division of Basic Sciences, MD Anderson Cancer Center, Houston, TX, USA.
Demetrius AlbanesDivision of Cancer Epidemiology & Genetics, US NCI, Bethesda, MD, USA.
Melinda C AldrichDepartment of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Adonina TardónFaculty of Medicine, University of Oviedo and ISPA and CIBERESP, Campus del Cristo, Oviedo, Spain.ORCID http://orcid.org/0000-0001-5150-1209
Gad RennertClalit National Cancer Control Center, Technion Faculty of Medicine, Haifa, Israel.ORCID http://orcid.org/0000-0002-8512-068X
Chu ChenFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gary E GoodmanFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jennifer A DohertyDepartment of Population Health Sciences, Huntsman Cancer Institute, Salt Lake City, UT, USA.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-Universität Göttingen, Göttingen, Germany.
John K FieldRoy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool, London, UK.
Michael P DaviesRoy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool, London, UK.
M Dawn TeareBiostatistics Research Group, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Lambertus A KiemeneyRadboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Stig E BojesenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.ORCID http://orcid.org/0000-0002-4061-4133
Aage HaugenThe National Institute of Occupational Health, Oslo, Norway.
Shanbeh ZienolddinyThe National Institute of Occupational Health, Oslo, Norway.
Stephen LamBC Cancer Agency, Vancouver, BC, Canada.
Loïc Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Iona ChengDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-3241-3216
Eric J DuellUnit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Angeline S AndrewDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Jonas ManjerSkåne University Hospital, Lund University, Lund, Sweden.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
Susanne ArnoldMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-6542-9551
James D McKayInternational Agency for Research on Cancer, Lyon, France.
Nima C EmamiDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Matthew T WarkentinProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Yonathan BrhaneProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Ma'en ObeidatUniversity of British Columbia, Centre for Heart Lung Innovation, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-5443-2752
Richard M MartinMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7992-7719
Caroline ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314
Philip C HaycockMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.ORCID http://orcid.org/0000-0002-0518-8714
John S WitteDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA. jwitte@ucsf.edu.
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.ORCID http://orcid.org/0000-0002-4486-7496
University of California, San Francisco · USCentre international de recherche sur le cancer · FRCancer Genetics (United States) · USUniversity of Bristol · GBFred Hutch Cancer Center · USInstitut universitaire de cardiologie et de pneumologie de Québec · CANational Institute of Occupational Health · NOUniversity of Liverpool · GBUniversity of Toronto · CABaylor College of Medicine · USBC Cancer Agency · CADartmouth College · USGentofte Hospital · DKHarvard University · USHuntsman Cancer Institute · USImperial College London · GBInstitut d'Investigació Biomédica de Bellvitge · ESLund University · SELunenfeld-Tanenbaum Research Institute · CAMoffitt Cancer Center · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Rayjean J. Hung · 2017 to 2026
$23.7MThe Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2MUnderstanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3MSPORE in Lung CancerP50CA119997 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GABRILOVICH, DMITRY I · 2008 to 2012
$11.0MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MTraining in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5MInfrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9MINFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORYUM1CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 2013 to 2017
$2.8MGenome-wide Pleiotropy Scan across Multiple CancersR01CA201358 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRAFF, REBECCA ELIZABETH, SAKODA, LORI · 2016 to 2019
$2.5MCancer Research UK 19169Cancer Research UK 20138Medical Research Council MC_PC_12028Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/5NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA119997NCI NIH HHS R01 CA111703NCI NIH HHS R01 CA151989NCI NIH HHS R01 CA201358NCI NIH HHS R25 CA112355NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA209414NCI NIH HHS U19 CA203654NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA167462World Health Organization 001
Abstract
Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV
Indexed as
AdultAgedFemaleForced Expiratory VolumeGenetic Predisposition to DiseaseHumansLungLung NeoplasmsMaleMendelian Randomization AnalysisMiddle AgedPhenotypePolymorphism, Single NucleotideProspective StudiesRespiratory Function TestsVital Capacity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.