ReviewNature reviews. Neuroscience2020
Mechanisms underlying gain modulation in the cortex.
Review in Nature reviews. Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.
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Who cites it
144 citing papers in PubMed, 337 citations in OpenAlex.
- The Ability to Voluntarily Regulate Theta Band Activity Affects How Pharmacological Manipulation of the Catecholaminergic System Impacts Cognitive Control.The international journal of neuropsychopharmacology · 2024Trial
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- Place and behavioral modulation of hippocampal neurons during immobility.Nature communications · 2026Article
- A personalized map of where, when, and how to stimulate the brain to elicit controlled responses.bioRxiv : the preprint server for biology · 2026Article
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- Decomposing the modulation of interactions between neuronal populations.bioRxiv : the preprint server for biology · 2026Article
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- Optimized feature gains explain and predict successes and failures of human selective listening.Nature human behaviour · 2026Article
- A multimodal approach for visualizing and identifying electrophysiological cell types in vivo.Nature communications · 2026Article
- Laminar-specific control of response gain and orientation-tuning by parvalbumin-expressing inhibitory interneurons in primate visual cortex.Research square · 2026Article
- 'Backpropagation and the brain' realized in cortical error neuron microcircuits.PLoS computational biology · 2026Article
- Overlap in neural representations of coordinated wrist and finger movements in human motor cortex.bioRxiv : the preprint server for biology · 2026Article
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- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Computing the effects of excitatory-inhibitory balance on neuronal input-output properties.PLoS computational biology · 2026Article
- Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states.Neuron · 2026Article
- Voltage imaging as a window into neural computation.Neurophotonics · 2026Article
- A Translational Neural Network Mechanism of Resilience: Top-Down Control and Plasticity of the Visual Cortex Relates to Resilient Outcome and Performance.Research (Washington, D.C.) · 2026Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural gain is modulated by internal and external influences, including attentional and arousal states, motor activity and neuromodulatory input. These influences converge to a common set of mechanisms for gain modulation, including GABAergic inhibition, synaptically driven fluctuations in membrane potential, changes in cellular conductance and changes in other biophysical neural properties. Recent work has identified GABAergic interneurons as targets of neuromodulatory input and mediators of state-dependent gain modulation. Here, we review the engagement and effects of gain modulation in the cortex. We highlight key recent findings that link phenomenological observations of gain modulation to underlying cellular and circuit-level mechanisms. Finally, we place these cellular and circuit interactions in the larger context of their impact on perception and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.