ArticleNature communications2020
Siah2 control of T-regulatory cells limits anti-tumor immunity.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
What it found
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Hyodeoxycholic acid attenuates atherosclerosis by antagonizing FXR and modulating the PD-1/mTORC1 signaling axis.Redox biology · 2026Article
- SIAH2-EPHB6 axis enhances filopodia formation in hepatocellular carcinoma cells by regulating RHOF.Cell & bioscience · 2026Article
- Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.Cell reports. Medicine · 2026Article
- New Insights Into the Role of Polo-Like Kinase 3 in Lung Tumorigenesis.Journal of cellular biochemistry · 2026Article
- HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins.bioRxiv : the preprint server for biology · 2025Article
- Regulatory T cells in cancer anti-PD-(L)1 therapy.Human cell · 2025Review
- Construction and validation of antibody dependent cell phagocytosis related risk model in breast cancer.Scientific reports · 2025Article
- Construction of a prognostic model and analysis of related mechanisms in breast cancer based on multiple datasets.Translational cancer research · 2025Article
- SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism.International journal of cancer · 2025Article
- Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers.PloS one · 2025Article
- The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity.Nature cell biology · 2024Article
- Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.Cancer research · 2023Article
- Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 (HDAC3) Stabilization and Chromatin Condensation.Cancer research communications · 2022Article
- Expression of the preadipocyte marker ZFP423 is dysregulated between well-differentiated and dedifferentiated liposarcoma.BMC cancer · 2022Article
- Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.Cell death & disease · 2022Article
- Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment.Frontiers in cell and developmental biology · 2022Review
- Proteasomal Degradation of Zn-Dependent Hdacs: The E3-Ligases Implicated and the Designed Protacs That Enable Degradation.Molecules (Basel, Switzerland) · 2021Review
- An Update on the Role of Ubiquitination in Melanoma Development and Therapies.Journal of clinical medicine · 2021Review
- Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Marzia ScortegagnaCancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. mscortegagna@sbpdiscovery.org.
Kathryn HockemeyerDepartment of Pathology and Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY, 10016, USA.
Igor DolgalevDepartment of Pathology and Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0003-4451-126X
Joanna PoźniakVIB Center for Cancer Biology Laboratory for Molecular Cancer Biology, KU Leuven Oncology Department, Leuven, Belgium.
Florian RambowVIB Center for Cancer Biology Laboratory for Molecular Cancer Biology, KU Leuven Oncology Department, Leuven, Belgium.
Yan Li
Yongmei FengCancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Roberto TinocoCancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0001-5420-9692
Dennis C OteroCancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-2124-2706
Kevin BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Marcus BosenbergDepartments of Dermatology, Pathology, Yale University, School of Medicine, New Haven, CT, 06520, USA.
Linda M BradleyCancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Jean-Christophe MarineVIB Center for Cancer Biology Laboratory for Molecular Cancer Biology, KU Leuven Oncology Department, Leuven, Belgium.
Ioannis AifantisDepartment of Pathology and Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY, 10016, USA. Ioannis.Aifantis@nyulangone.org.
Ze'ev A RonaiCancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. zeev@ronailab.net.ORCID http://orcid.org/0000-0002-3859-0400
Sanford Burnham Prebys Medical Discovery Institute · USNYU Langone’s Laura and Isaac Perlmutter Cancer CenterVIB-KU Leuven Center for Cancer Biology · BENational Cancer Institute · USYale University · US
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MTumor Assessment CoreP01CA128814 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SMITH, JEFFREY W · 2009 to 2020
$19.1MRewired Signaling at the Nexus of Melanoma Metastasis and ResistanceR35CA197465 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RONAI, ZEEV A. · 2016 to 2022
$7.9MMapping cancer micro-environments for acute leukemiaR01CA202025 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AIFANTIS, IANNIS, SCHWAB, SUSAN RUTH · 2016 to 2020
$2.3MPost-translational control of cancer cell stress response and metastasisR01CA202027 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AIFANTIS, IANNIS, HERNANDO, EVA · 2016 to 2020
$2.3MAltered Dependencies of Melanoma on Rewired Post-Transcriptional RegulationF30CA232704 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOCKEMEYER, KATHRYN GRACE · 2019 to 2022
$152kNCI NIH HHS P01 CA128814NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA202025NCI NIH HHS R01 CA202027NCI NIH HHS R35 CA197465
Abstract
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2
Indexed as
AnimalsChemokine CCL17Chemokine CCL22Forkhead Box Protein O3HumansMelanomaMiceMice, KnockoutNuclear ProteinsSeven in Absentia ProteinsT-Lymphocytes, RegulatoryUbiquitin-Protein LigasesChemokine CCL17Chemokine CCL22Forkhead Box Protein O3Nuclear ProteinsSeven in Absentia ProteinsSiah2 protein, mouseUbiquitin-Protein Ligases
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.