ArticleNature communications2020
High-density information storage in an absolutely defined aperiodic sequence of monodisperse copolyester.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 91 citations in OpenAlex.
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- Template-based copying in chemically fuelled dynamic combinatorial libraries.Nature chemistry · 2024Article
- Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution.Journal of the American Chemical Society · 2024Review
- Synthetically encoded complementary oligomers.Nature reviews. Chemistry · 2023Review
- Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes.Journal of the American Chemical Society · 2022Article
- Nondestructive Sequencing of Enantiopure Oligoesters by Nuclear Magnetic Resonance Spectroscopy.JACS Au · 2022Article
- Molecular Encryption and Steganography Using Mixtures of Simultaneously Sequenced, Sequence-Defined Oligourethanes.ACS central science · 2022Article
- Oxygen-Tolerant RAFT Polymerization Initiated by Living Bacteria.ACS macro letters · 2022Article
- Paramagnetic encoding of molecules.Nature communications · 2022Article
- Semiautomated synthesis of sequence-defined polymers for information storage.Science advances · 2022Article
- Efficient molecular encoding in multifunctional self-immolative urethanes.Cell reports. Physical science · 2021Article
- Applications of Discrete Synthetic Macromolecules in Life and Materials Science: Recent and Future Trends.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Reading mixtures of uniform sequence-defined macromolecules to increase data storage capacity.Communications chemistry · 2020Article
- Decoding DNA data storage for investment.Biotechnology advances · 2020Review
- Solid-Phase Synthesis of Sequence-Defined Informational Oligomers.The Journal of organic chemistry · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthesis of a polymer composed of a large discrete number of chemically distinct monomers in an absolutely defined aperiodic sequence remains a challenge in polymer chemistry. The synthesis has largely been limited to oligomers having a limited number of repeating units due to the difficulties associated with the step-by-step addition of individual monomers to achieve high molecular weights. Here we report the copolymers of α-hydroxy acids, poly(phenyllactic-co-lactic acid) (PcL) built via the cross-convergent method from four dyads of monomers as constituent units. Our proposed method allows scalable synthesis of sequence-defined PcL in a minimal number of coupling steps from reagents in stoichiometric amounts. Digital information can be stored in an aperiodic sequence of PcL, which can be fully retrieved as binary code by mass spectrometry sequencing. The information storage density (bit/Da) of PcL is 50% higher than DNA, and the storage capacity of PcL can also be increased by adjusting the molecular weight (~38 kDa).
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Registered trials
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