ReviewNature communications2020
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies.
Erratum issuedOpen access · goldAbstract readReview
In one paragraph
Review in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 75 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.Genome medicine · 2024Pooled it
- Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.Nature communications · 2022Pooled it
- Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Analysis of whole genome sequencing and plasma metabolomics unveil genetic determinants and clinical implications for human health.Nature communications · 2026Article
- Multi-omics dissection of heat stress reveals CIITA as a central regulator of metabolic thermotolerance in cattle (Bos taurus).Communications biology · 2026Article
- The MetaboHealth score is 40% heritable and is influenced by frailty status, BMI, and smoking in Swedish twins.GeroScience · 2026Article
- Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs.Genetics, selection, evolution : GSE · 2026Article
- Statistical modelling of an outcome variable with integrated multi-omics.BMC bioinformatics · 2025Article
- Plasma Metabolite Profiles of Children with Autism Spectrum Disorder.Metabolites · 2025Article
- Exploring Causal Associations Between Plasma Metabolites and Autism Spectrum Disorder.Alpha psychiatry · 2025Article
- Causal relationship between gut microbiota, metabolites, and short stature: a Mendelian randomization study.Pediatric research · 2025Article
- Genetic architecture of plasma metabolome in 254,825 individuals.Nature communications · 2025Article
- The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians.BMC medicine · 2025Observational
- Gene-Embedded Multi-Modal Networks for Population-Scale Multi-Omics Discovery.bioRxiv : the preprint server for biology · 2025Article
- Genetically Predicted 1400 Blood Metabolites in Relation to Risk of Prostate Cancer: A Mendelian Randomization Study.Aging medicine (Milton (N.S.W)) · 2025Article
- Circulating metabolic biomarkers mediated causal relationship between gut microbiota and bladder cancer: a two-step mendelian randomization study.Discover oncology · 2025Article
- Exploring causal associations between plasma metabolites and attention-deficit/hyperactivity disorder.BMC psychiatry · 2025Article
- Causal roles of lipids and mediating proteins in diabetic retinopathy: insights from metabolomic and proteomic Mendelian randomization.Diabetology & metabolic syndrome · 2025Article
- Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits.Scientific reports · 2025Article
- Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways.Genetics, selection, evolution : GSE · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 17 institutions in 2 countries.
Fiona A HagenbeekDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. f.a.hagenbeek@vu.nl.
René PoolDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5579-0933
Jenny van DongenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2063-8741
Harmen H M DraismaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Jouke Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Abdel AbdellaouiDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Iryna O FedkoDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Anouk den BraberDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3377-2627
Pieter Jelle VisserAlzheimer Center Amsterdam, Department of Neurology, VU Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8008-9727
Eco J C N de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6022-2666
Ko Willems van DijkEinthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-2172-7394
Aswin VerhoevenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0373-9372
H Eka SuchimanDepartment of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-7168-5516
Marian BeekmanDepartment of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0585-6206
P Eline SlagboomDepartment of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-2875-4723
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
BBMRI Metabolomics Consortium
Amy C HarmsDivision of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University and The Netherlands Metabolomics Centre, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-2931-4295
Thomas HankemeierDivision of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University and The Netherlands Metabolomics Centre, Leiden, The Netherlands.
Meike BartelsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9667-7555
Michel G NivardDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. m.g.nivard@vu.nl.ORCID http://orcid.org/0000-0003-2015-1888
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. di.boomsma@vu.nl.ORCID http://orcid.org/0000-0002-7099-7972
Leiden University Medical Center · NLUniversity Medical Center Groningen · NLAmsterdam Neuroscience · NLLeiden University · NLVrije Universiteit Amsterdam · NLErasmus MC · NLMaastricht University · NLUniversity Medical Center Utrecht · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLSanquin · NLAmsterdam Public Health · NLAmsterdam University Medical Centers · NLErasmus University Rotterdam · NLPublic Health Service of Amsterdam · NLUniversity of Amsterdam · NLUniversity of Bonn · DEWageningen University & Research · NL
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MIntegration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5MGenomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8MCollaborative Study of Genetics of Dizygotic TwinningR01HD042157 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MONTGOMERY, GRANT W · 2002 to 2006
$2.0MMajor Depression: Stage 1 Genomewide Association in Population-Based SamplesR01MH081802 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2007
$138kEPA EP-C-15-001NICHD NIH HHS R01 HD042157NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U24 MH068457
Abstract
Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h
Indexed as
Genome-Wide Association StudyBloodBlood Chemical AnalysisCohort StudiesHumansMetabolomicsQuantitative Trait LociTwins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.