ArticlePsychoneuroendocrinology2020
Oxytocin during breastfeeding and maternal mood symptoms.
Article in Psychoneuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Desired but Unattained Breastfeeding: A Qualitative Exploration of Maternal Perceptions in a Cultural-Religious Context.Nursing reports (Pavia, Italy) · 2026Article
- Beyond lactation: Central oxytocin in maternal mental health and disease.Neuroscience and biobehavioral reviews · 2026Review
- Perinatal depression and breastfeeding: a longitudinal investigation of the bidirectional relationship in Pakistan.Archives of women's mental health · 2026Article
- Postpartum Depression and the Emerging Mother-Infant Relationship: Associations With Selective Serotonin Reuptake Inhibitor Medication Use.JAACAP open · 2026Article
- Prolonged breastfeeding and hypertension risk among Kenyan women: exploring the roles of obesity and alcohol consumption.Journal of health, population, and nutrition · 2026Article
- Breastfeeding in the Context of Trauma and Previous Psychological Experiences: A Narrative Review.Nutrients · 2026Review
- Oxytocin Attenuates Metabolic Dysfunction-associated Steatotic Liver Disease via AMPK/SREBP1c/FAS-mediated Suppression of Hepatic Lipogenesis.Journal of clinical and translational hepatology · 2026Article
- When Your Body Tells You to Not Breastfeed-The Connivance of Oxytocin, Prolactin, and Dopamine.International journal of molecular sciences · 2025Review
- Postpartum Depression Epidemiology, Risk Factors, Diagnosis, and Management: An Appraisal of the Current Knowledge and Future Perspectives.Journal of clinical medicine · 2025Review
- HPA axis dysregulation and postpartum depression and anxiety symptoms in breastfeeding vs bottle-feeding parents.Psychoneuroendocrinology · 2025Article
- Interoception in pregnancy: Implications for peripartum depression.Neuroscience and biobehavioral reviews · 2024Review
- Investigation and Analysis of Emotional State and Oxytocin Level in Patients with Postpartum Depression.Actas espanolas de psiquiatria · 2024Article
- Association of Perinatal Depressive Symptoms with Breastfeeding.Alpha psychiatry · 2024Article
- Breast milk oxytocin and s-IgA modulate infant biomarkers and social engagement; The role of maternal anxiety.Comprehensive psychoneuroendocrinology · 2024Article
- Breastfeeding and Postpartum Depression: A Review of Relationships and Potential Mechanisms.Current psychiatry reports · 2023Review
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- The Mood, Mother and Child Study: Protocol for a Prospective Longitudinal Study and Randomized Controlled Trial.JMIR research protocols · 2023Article
- The transition to motherhood: linking hormones, brain and behaviour.Nature reviews. Neuroscience · 2023Review
- Nursing model of midwifery and postural and psychological interventions: Impact on maternal and fetal outcomes and negative emotions of primiparas.World journal of psychiatry · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
This study aimed to quantify the relationship between postpartum depression and anxiety, oxytocin, and breastfeeding. We conducted a longitudinal prospective study of mother-infant dyads from the third trimester of pregnancy to 12 months postpartum. A sample of 222 women were recruited to complete the Beck Depression Inventory II and Spielberger State-Trait Anxiety Inventory-state subscale, participate in observed infant feeding sessions at 2 and 6 months postpartum, and provide venous blood samples during feeding. Maternal venous oxytocin levels in EDTA-treated plasma and saliva were determined by enzyme immunoassay with extraction and a composite measure of area under the curve (AUC) was used to define oxytocin across a breastfeeding session. Linear regression was used to estimate associations between postpartum depression and anxiety as predictors and oxytocin AUC during breastfeeding as the outcome at both 2 and 6 months postpartum. Mixed models accounting for correlations between repeated oxytocin measures were used to quantify the association between current depression and/or anxiety symptoms and oxytocin profiles during breastfeeding. We found no significant differences in oxytocin AUC across a feed between depressed or anxious women and asymptomatic women at either 2 or 6 months postpartum. Repeated measures analyses demonstrated no differences in oxytocin trajectories during breastfeeding by symptom group but possible differences by antidepressant use. Our study suggests that external factors may influence the relationship between oxytocin, maternal mood symptoms, and infant feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.