Evidence map›Paper›PMID 31911305›Full record

ArticleBioorganic chemistry2020

Design, synthesis and SAR study of 3rd-generation taxoids bearing 3-CH

Changwei Wang, Xin Wang, Yi Sun, Adam K Taouil, Su Yan, Galina I Botchkina, Iwao Ojima

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. MgJACS Au · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Changwei WangDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA; Drug Discovery Pipeline, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China.
Xin WangDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Yi SunDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Adam K TaouilDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Su YanDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Galina I BotchkinaInstitute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Iwao OjimaDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA. Electronic address: iwao.ojima@stonybrook.edu.
Stony Brook University · US

Funding

Tumor -Targeting Chemotherapeutic AgentsR01CA103314 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI OJIMA, IWAO · 2003 to 2013
$3.1M
NCI NIH HHS R01 CA103314
6 · The paper itself

Abstract

It has been shown that inclusion of CF

Indexed as

Drug DesignAntineoplastic Agents, PhytogenicBenzoatesCell Line, TumorDrug Resistance, NeoplasmHumansNeoplastic Stem CellsStructure-Activity RelationshipTaxoidsAntineoplastic Agents, PhytogenicBenzoatesTaxoids3rd-generation taxoidCancer stem cellsDifluoromethoxyFluorine-containingMultidrug resistanceSAR studyTaxaneTrifluoromethoxy

Identifiers

PMID31911305
PMCPMC7561017
OpenAlexW2996371279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.