ArticleMagnetic resonance imaging2020
Detecting sub-voxel microvasculature with USPIO-enhanced susceptibility-weighted MRI at 7 T.
Article in Magnetic resonance imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Evaluation of Phantom Doping Materials in Quantitative Susceptibility Mapping.Magnetic resonance in medicine · 2026Article
- Validation of deep-learning accelerated quantitative susceptibility mapping for deep brain nuclei.Frontiers in neuroscience · 2025Article
- Shedding light on vascular imaging: the revolutionary role of nanotechnology.Journal of nanobiotechnology · 2024Review
- In Vivo Detection of Age-Related Tortuous Cerebral Small Vessels using Ferumoxytol-enhanced 7T MRI.Aging and disease · 2024Article
- The role of the parenchymal vascular system in cerebrospinal fluid tracer clearance.European radiology · 2023Article
- Article
- Acceleration of Brain Susceptibility-Weighted Imaging with Compressed Sensitivity Encoding: A Prospective Multicenter Study.AJNR. American journal of neuroradiology · 2022Article
- An Overview of Venous Abnormalities Related to the Development of Lesions in Multiple Sclerosis.Frontiers in neurology · 2021Review
- Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO.NeuroImage. Clinical · 2021Article
- The Efficacy of 18F-FDG PET/CT and Superparamagnetic Nanoferric Oxide MRI in the Diagnosis of Lung Cancer and the Value of 18F-FDG PET/CT in the Prediction of Lymph Node Metastasis.Computational and mathematical methods in medicine · 2021Article
- Three-Dimensional Iron Oxide Nanoparticle-Based Contrast-Enhanced Magnetic Resonance Imaging for Characterization of Cerebral Arteriogenesis in the Mouse Neocortex.Frontiers in neuroscience · 2021Article
- Characterizing the Neuroimaging and Histopathological Correlates of Cerebral Small Vessel Disease in Spontaneously Hypertensive Stroke-Prone Rats.Frontiers in neurology · 2021Article
- Subvoxel vascular imaging of the midbrain using USPIO-Enhanced MRI.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundSusceptibility weighted imaging (SWI) combines phase with magnitude information to better image sub-voxel veins. Recently, it has been extended to image very small sub-voxel arteries and veins by injecting intravenously the ultra-small superparamagnetic iron oxide, Ferumoxytol.
objectiveTo determine practical experimental imaging parameters for sub-voxel cerebral vessels at 7 T.
methodsSix Wistar-Kyoto rats aged 7-13 weeks were imaged. For a given spatial resolution, SWI was acquired pre- and post- Ferumoxytol with doses of 2, 4, 6 and 8 mg/kg and echo times (TEs) of 5, 10 and 15 ms at each dose. The spatial resolutions of 62.5 × 125 × 250 μm
resultsFor a given spatial resolution with an aspect ratio (frequency: phase: slice) of 2:4:8 relative to the vessel size, we found the TE-dose index (TE x dose) must be at least 40 ms·mg/kg for both SWI and QSM to reveal the most vessels. The higher the TE-dose index, the better the image quality for both SWI and QSM up to 60 ms·mg/kg.
conclusionsThere is an optimal TE-dose index for improved visualization of sub-voxel vessels. Choosing the smallest TE and the largest allowed dose made it possible to run the sequence efficiently. In practice, the aspect ratio of 2:4:8 and the TE-dose index ranging from 40 to 60 ms·mg/kg provided the optimal and most practical solution.
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