ArticleInternational psychogeriatrics2020
Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits.
Article in International psychogeriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Depressive symptoms exacerbate disability in older adults: A prospective cohort analysis of participants in the MemAID trial.PloS one · 2022Trial
- Viewpoints of Healthcare Professionals on Care Delivery Within the Frames of Old-Age Mental Telehealth Services Operating in Low-Resource Settings.Brain sciences · 2025Article
- Article
- Telehealth memory clinics in primary healthcare: real-world experiences from low-resource settings in Greece.Frontiers in dementia · 2024Article
- Old-age mental telehealth services at primary healthcare centers in low- resource areas in Greece: design, iterative development and single-site pilot study findings.BMC health services research · 2023Article
- The Relationship between Neuropsychiatric Symptoms and Cognitive Performance in Older Adults with Normal Cognition.Medicina (Kaunas, Lithuania) · 2022Article
- Feasibility of Problem Adaption Therapy in a Diverse, Frail Older Adult Population (PATH-MHS).The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- The effects of modified problem-solving therapy on depression, coping, and self-efficacy in elderly nursing home residents.Frontiers in psychology · 2022Article
- Home/community-based interventions to improve function in persons with mild cognitive impairment/early dementia.Geriatric nursing (New York, N.Y.)Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesAntidepressants have limited efficacy in older adults with depression and cognitive impairment, and psychosocial interventions for this population have been inadequately investigated. Problem Adaptation Therapy (PATH) is a psychosocial intervention for older adults with major depression, cognitive impairment, and disability.
designThis study tests the efficacy of PATH versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in reducing depression (Montgamery Asberg Depression Rating Scale [MADRS]) and disability (World Health Organization Disability Assessments Schedule-II [WHODAS-II]) and improving cognitive outcomes (Mini Mental State Examination [MMSE]) over 24 weeks (12 weeks of treatment and 12-week post-treatment follow-up).
settingParticipants were recruited through collaborating community agencies of Weill Cornell Institute of Geriatric Psychiatry. Both interventions and all research assessments were conducted at home.
participantsThirty-five older adults (age ≥ 65 years) with major depression and cognitive impairment no dementia (CIND).
interventionsPATH aims to increase emotion regulation by incorporating a problem-solving approach, teaching compensatory strategies, and inviting caregiver participation. Supportive Therapy aims to facilitate the expression of affect, as well as promote empathy. MEASUREMENTS: Depression was measured using the MADRS, disability using the WHODAS-II, and cognition using the MMSE.
resultsPATH participants showed significantly greater reduction in MADRS total score (7.04 points at 24 weeks, treatment group by time interaction: F[1,24.4] = 7.61, p = 0.0108), greater improvement in MMSE total score (2.30 points at 24 weeks, treatment group by time interaction: F[1,39.8] = 13.31, p = 0.0008), and greater improvement in WHODAS-II total score (2.95 points at 24 weeks, treatment group by time interaction: F[1,89] = 4.93, p = 0.0290) than ST-CI participants over the 24-week period.
conclusionsPATH participants had better depression, cognitive, and disability outcomes than ST-CI participants over 6 months. PATH may provide relief to depressed older adults with CIND who currently have limited treatment options.
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