ArticleGenome biology2020
Chromatin interactome mapping at 139 independent breast cancer risk signals.
Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.Nature genetics · 2020Pooled it
- BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans.Molecular cancer · 2026Article
- Unveiling Epigenetic Regulatory Elements Associated with Breast Cancer Development.International journal of molecular sciences · 2025Article
- Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets.American journal of human genetics · 2025Article
- Integration of chromosome conformation and gene expression networks reveals regulatory mechanisms in triple negative breast cancer.Frontiers in cell and developmental biology · 2025Article
- RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer.EMBO reports · 2024Article
- GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers.PLoS genetics · 2024Article
- CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair.Molecular cancer · 2024Article
- MMDRP: drug response prediction and biomarker discovery using multi-modal deep learning.Bioinformatics advances · 2024Article
- CRISPR screens identify gene targets at breast cancer risk loci.Genome biology · 2023Article
- Functional studies of lung cancer GWAS beyond association.Human molecular genetics · 2022Review
- Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer.Cold Spring Harbor perspectives in medicine · 2022Review
- YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.Cell death and differentiation · 2022Article
- Functional annotation of breast cancer risk loci: current progress and future directions.British journal of cancer · 2022Review
- Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure.BMC genomic data · 2022Article
- Mutations in NoncodingMolecular cancer research : MCR · 2022Article
- Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility.Nature communications · 2021Article
- Gene Co-Expression in Breast Cancer: A Matter of Distance.Frontiers in oncology · 2021Article
- eQTL Colocalization Analyses Identify NTN4 as a Candidate Breast Cancer Risk Gene.American journal of human genetics · 2020Article
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Authors and funding
24 authors.
Funding
Abstract
backgroundGenome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these signals frequently fall in distal regulatory DNA elements that control gene expression.
resultsWe designed a Capture Hi-C array to enrich for chromatin interactions between the credible causal variants and target genes in six human mammary epithelial and breast cancer cell lines. We show that interacting regions are enriched for open chromatin, histone marks for active enhancers, and transcription factors relevant to breast biology. We exploit this comprehensive resource to identify candidate target genes at 139 independent breast cancer risk signals and explore the functional mechanism underlying altered risk at the 12q24 risk region.
conclusionsOur results demonstrate the power of combining genetics, computational genomics, and molecular studies to rationalize the identification of key variants and candidate target genes at breast cancer GWAS signals.
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