ArticleStroke2020
Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.
Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Angiotensin II impairs the remyelination mediated by brain endothelial cell-derived exosomes.Acta neuropathologica communications · 2026Article
- DNA methylation signatures of Life's Essential 8 and their implications for dementia.Alzheimer's research & therapy · 2025Article
- Blood pressure at age 40 and key features of cerebral small vessel disease at age 70: data from the ACE 1950 Study.BMC cardiovascular disorders · 2025Observational
- Racial ethnic variations in the cardiometabolic determinants and blood pressure of white matter hyperintensities among females-The HABS-HD Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study.Stroke · 2025Review
- Sex-Specific Vulnerabilities to Subclinical Vascular Brain Injury in Early Late-Life: The Framingham Heart Study.Annals of neurology · 2025Article
- Sex differences in the association of cardiometabolic risk scores and blood pressure measurements with white matter hyperintensities in diverse older adults-HABS-HD.Frontiers in aging neuroscience · 2025Article
- Association of estimated pulse wave velocity with cognitive function in a multiethnic diverse population: The Northern Manhattan Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- Blood Pressure Partially Mediated the Association of Insulin Resistance and Cerebral Small Vessel Disease: A Community-Based Study.Journal of the American Heart Association · 2024Observational
- Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study.Environmental health perspectives · 2023Article
- Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The Shanghai Changfeng study.Human brain mapping · 2023Article
- Investigating the factors that explain white matter hyperintensity load in older Indians.Brain communications · 2023Article
- Optimal systolic and diastolic blood pressure threshold that associated with lower risk of white matter hyperintensity progression.Frontiers in aging neuroscience · 2023Article
- Development and validation of a predictive model for white matter lesions in young- and middle-aged people.Frontiers in neurology · 2023Article
- Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure.Journal of the American Heart Association · 2022Article
- Effects of Higher Normal Blood Pressure on Brain Are Detectable before Middle-Age and Differ by Sex.Journal of clinical medicine · 2022Article
- Plasma aldosterone concentration is associated with white matter lesions in patients with primary aldosteronism.Endocrine · 2022Article
- Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults.Frontiers in integrative neuroscience · 2022Article
- White matter hyperintensity volume in pre-diabetes, diabetes and normoglycemia.BMJ open diabetes research & care · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Background and Purpose- Few studies have examined the separate contributions of systolic blood pressure and diastolic blood pressures (DBP) on subclinical cerebrovascular disease, especially using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. Furthermore, associations with region-specific white matter hyperintensity volume (WMHV) are underexplored. Methods- Using data from the NOMAS (Northern Manhattan Study), a prospective cohort study of stroke risk and cognitive aging, we examined associations between systolic blood pressure and DBP, defined by the 2017 American College of Cardiology/American Heart Association guidelines, with regional WMHV. We used a linear mixed model approach to account for the correlated nature of regional brain measures. Results- The analytic sample (N=1205; mean age 64±8 years) consisted of 61% women and 66% Hispanics/Latinos. DBP levels were significantly related to WMHV differentially across regions (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.