SynthesisCaries research2020
How to Intervene in the Caries Process: Early Childhood Caries - A Systematic Review.
Synthesis in Caries research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Do systematic reviews of non- and micro-invasive treatment for caries lesions in children and adolescents adhere to the PRISMA reporting guidelines? A meta-research.Evidence-based dentistry · 2026Pooled it
- Mapping Systematic Reviews on the Management of Dental Caries in Primary Teeth: A Meta-research.Current pediatric reviews · 2026Pooled it
- Impact of dental treatments under general anesthesia on oral health-related quality of life in children: a comprehensive meta-analysis.BMC oral health · 2025Pooled it
- Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults.The Cochrane database of systematic reviews · 2024Pooled it
- Pooled it
- Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial.International dental journal · 2025Trial
- Clinical effectiveness/child-patient and parent satisfaction of two topical fluoride treatments for caries: a randomised clinical trial.Scientific reports · 2024Trial
- Knowledge and attitude regarding preventive and minimally invasive caries treatments: a cross-sectional survey among Dutch dental professionals.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Evaluation of Treatment Approaches Adopted by General Dentists for Early Childhood Caries.Cureus · 2026Article
- Minimum Intervention Oral Care (MIOC) - Overcoming Implementation Barriers: An International Expert Consensus.International dental journal · 2026Article
- An Integrated Care Pathway for Pediatric Oral Health: Baseline Multicenter Analysis of Dental Caries, Malocclusions, and Oral Hygiene in Three Italian Regions.Children (Basel, Switzerland) · 2026Article
- Economic Evaluations of Preventive and Minimally Invasive Children's Dental Caries Procedures: A Scoping Review.Caries research · 2026Article
- Preparation of silver-loaded metal-organic frameworks as a novel agent for arresting dental caries of primary teeth.Scientific reports · 2025Article
- Quality of YouTube™ videos on the clinical use of silver fluoride.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Study of severe early childhood caries in children under general anesthesia from a single hospital.Scientific reports · 2025Article
- Clinical Pathways in Managing High-Caries Children with Adverse Dental Histories.Medicina (Kaunas, Lithuania) · 2025Article
- Fluoride Release from Pediatric Dental Restorative Materials: A Laboratory Investigation.Dentistry journal · 2025Article
- Conceptual modelling of the factors affecting parental acceptance of silver diamine fluoride.BMC oral health · 2025Observational
- Assessment of Trends in Non-Restorative and Preventative Dental Treatment Pre- and Post-COVID-19: A Health Informatics Pilot Study.Children (Basel, Switzerland) · 2025Article
- Updates on Caries Management in the Primary and Permanent Dentition.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For an Organisation for Caries Research/European Federation of Conservative Dentistry consensus, this systematic review is aimed to assess the question of how to manage the caries process in the case of early childhood caries (ECC). Medline via PubMed was searched systematically regarding management of ECC. First priority was existing systematic reviews or randomized clinical trials otherwise cohort studies dealing with management of ECC, primarily with carious anterior teeth. After data extraction, the potential risk of bias was estimated depending on the study types, and the level of evidence was evaluated. Regarding management of ECC, results are presented for silver diamine fluoride (SDF, n = 5), nonoperative caries management (NOCM, n = 10), and restorative approaches (RA, n = 8) separately, as different kinds of studies with different levels of evidence were found for the different aspects in the management of ECC. The 5 systematic reviews on SDF showed a high potential for arrest of ECC on a high level of evidence. In NOCM, a low level of evidence for a moderate effect of fluoride varnish in arresting or remineralizing, especially non-cavitated lesions, was assessed. For RA in carious anterior upper primary teeth, a low level of evidence was found for higher failure rates of glass ionomer cement and composite fillings than composite strip crowns even if placed under general anaesthesia and especially compared to other crowns (stainless steel and zirconia). In conclusions, ECC may be managed successfully with nonoperative (SDF, regular fluoride application) and moderately well with operative approaches, but the decision is affected by many other variables such as pulpal involvement, the child's cooperation, or a general anaesthesia setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.