Evidence map›Paper›PMID 31910245›Full record

ArticleMDM policy & practice

How Should the Value Attributes of Novel Antibiotics Be Considered in Reimbursement Decision Making?

Alec Morton, Abigail Colson, Axel Leporowski, Anna Trett, Taimur Bhatti, Ramanan Laxminarayan

Abstract read
In one paragraph

Article in MDM policy & practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Advance Market Commitments and Their Role in Public Innovation.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Attributable Length of Stay, Mortality Risk, and Costs of Bacterial Health Care-Associated Infections in Australia: A Retrospective Case-cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  10. Financing Pull Mechanisms for Antibiotic-Related Innovation: Opportunities for Europe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alec MortonUniversity of Strathclyde, Glasgow, UK.ORCID https://orcid.org/0000-0003-3803-8517
Abigail ColsonUniversity of Strathclyde, Glasgow, UK.
Axel LeporowskiUniversity of Heidelberg, Heidelberg, Germany.
Anna TrettUniversity of Strathclyde, Glasgow, UK.
Taimur BhattiF. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland.
Ramanan LaxminarayanUniversity of Strathclyde, Glasgow, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotics have revolutionized the treatment of bacterial infections. However, it is widely held that there is underinvestment in antibiotics research and development relative to the socially optimal level for a number of reasons. In this article, we discuss whether existing health technology assessment procedures recognize the full economic and societal value of new antibiotics to patients and society when making reimbursement decisions. We present three recommendations for modelling the unique attributes of value that are specific to novel antibiotics. We find, based on a review of the literature, that some of the value elements proposed by our framework have previously been discussed qualitatively by health technology assessment bodies when evaluating antibiotics, but are not yet formally captured via modelling. We present a worked example to show how it may be possible to capture these dimensions of value in a more quantitative manner. We conclude by answering the question of the title as follows: the unique attributes of novel antibiotics

Indexed as

antibiotic resistanceantibioticshealth technology assessmentreimbursement

Identifiers

PMID31910245
PMCPMC6935770

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.