ArticlePloS one2020
Impact of viral disease hypophagia on pig jejunal function and integrity.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Dietary soybean-derived trypsin inhibitor protein reduces nursery pig performance and may exacerbate F18 enterotoxigenic Escherichia coli disease.Journal of animal science · 2026Article
- Evaluation of dietary crude protein and non-starch polysaccharidase on nursery pig performance, nitrogen retention, hindgut fermentation and health.Translational animal science · 2026Article
- Acute enhanced liquid aspirin administration improves performance and intestinal function in nursery pigs.Journal of animal science · 2025Article
- Feed restriction as a model for small intestinal permeability in nursery pigs.Journal of animal science · 2025Article
- Insights into high-altitude adaptation and meat quality regulation by gastrointestinal metabolites in Tibetan and black pigs.Frontiers in veterinary science · 2025Article
- Evaluation of F18 enterotoxigenicFrontiers in veterinary science · 2025Article
- MiR-181a Negatively Regulates Claudin-3 to FacilitateViruses · 2024Article
- Effects of dietary protein level on intestinal function and inflammation in nursery pigs.Journal of animal science · 2024Article
- Effect of fermented rapeseed meal on growth performance, nutrient digestibility, and intestinal health in growing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Dairy Cows Are Limited in Their Ability to Increase Glucose Availability for Immune Function during Disease.Animals : an open access journal from MDPI · 2023Article
- Enhancing the nutritive value of canola meal for broiler chickens through enzymatic modifications.Journal of animal science · 2023Article
- Maternal immune activation and dietary soy isoflavone supplementation influence pig immune function but not muscle fiber formation.Journal of animal science · 2022Article
- Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.Veterinary research · 2021Article
- Lawsonia intracellularis infected enterocytes lack sucrase-isomaltase which contributes to reduced pig digestive capacity.Veterinary research · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogen challenges are often accompanied by reductions in feed intake, making it difficult to differentiate impacts of reduced feed intake from impacts of pathogen on various response parameters. Therefore, the objective of this study was to determine the impact of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and feed intake on parameters of jejunal function and integrity in growing pigs. Twenty-four pigs (11.34 ± 1.54 kg BW) were randomly selected and allotted to 1 of 3 treatments (n = 8 pigs/treatment): 1) PRRSV naïve, ad libitum fed (Ad), 2) PRRSV-inoculated, ad libitum fed (PRRS+), and 3) PRRSV naïve, pair-fed to the PRRS+ pigs' daily feed intake (PF). At 17 days post inoculation, all pigs were euthanized and the jejunum was collected for analysis. At days post inoculation 17, PRRS+ and PF pigs had decreased (P < 0.05) transepithelial resistance compared with Ad pigs; whereas fluorescein isothiocyanate-dextran 4 kDa permeability was not different among treatments. Active glucose transport was increased (P < 0.05) in PRRS+ and PF pigs compared with Ad pigs. Brush border carbohydrase activity was reduced in PRRS+ pigs compared with PF pigs for lactase (55%; P = 0.015), sucrase (37%; P = 0.002), and maltase (30%; P = 0.015). For all three carbohydrases, Ad pigs had activities intermediate that of PRRS+ and PF pigs. The mRNA abundance of the tight junction proteins claudin 2, claudin 3, claudin 4, occludin, and zonula occludens-1 were reduced in PRRS+ pigs compared with Ad pigs; however, neither the total protein abundance nor the cellular compartmentalization of these tight junction proteins differed among treatments. Taken together, this study demonstrates that the changes that occur to intestinal epithelium structure, function, and integrity during a systemic PRRSV challenge can be partially explained by reductions in feed intake. Further, long term adaptation to PRRSV challenge and caloric restriction does reduce intestinal transepithelial resistance but does not appear to reduce the integrity of tight junction protein complexes.
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