ArticlePLoS computational biology2020
Increasing growth rate slows adaptation when genotypes compete for diffusing resources.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Biophysical metabolic modeling of complex bacterial colony morphology.Cell systems · 2025Article
- Selection for toxin production in spatially structured environments increases with growth rate.The ISME journal · 2025Article
- Predicting partner fitness based on spatial structuring in a light-driven microbial community.PLoS computational biology · 2023Article
- Nitrogen use aggravates bacterial diversity and network complexity responses to temperature.Scientific reports · 2022Article
- Contribution of the genomic and nutritional differentiation to the spatial distribution of bacterial colonies.Frontiers in microbiology · 2022Article
- Correlation between the spatial distribution and colony size was common for monogenetic bacteria in laboratory conditions.BMC microbiology · 2021Article
- Slightly beneficial genes are retained by bacteria evolving DNA uptake despite selfish elements.eLife · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The rate at which a species responds to natural selection is a central predictor of the species' ability to adapt to environmental change. It is well-known that spatially-structured environments slow the rate of adaptation due to increased intra-genotype competition. Here, we show that this effect magnifies over time as a species becomes better adapted and grows faster. Using a reaction-diffusion model, we demonstrate that growth rates are inextricably coupled with effective spatial scales, such that higher growth rates cause more localized competition. This has two effects: selection requires more generations for beneficial mutations to fix, and spatially-caused genetic drift increases. Together, these effects diminish the value of additional growth rate mutations in structured environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.