ArticleActa bio-medica : Atenei Parmensis2019
Improved efficiency and cost reduction in the emergency department by replacing contemporary sensitive with high-sensitivity cardiac troponin immunoassay.
Article in Acta bio-medica : Atenei Parmensis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Emergency Department Implementation of a Multimodal Electronic Health Record-Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency.Journal of the American College of Emergency Physicians open · 2025Article
- Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects.Materials today. Bio · 2022Review
- Downstream Cascades of Care Following High-Sensitivity Troponin Test Implementation.Journal of the American College of Cardiology · 2021Observational
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough unquestionable evidence has been provided that high-sensitive (HS) cardiac troponin (cTn) immunoassay outperform the former contemporary-sensitive techniques, some clinicians are still hesitant to implement HS methods in routine clinical practice. This study was hence planned to evaluate the impact of replacing a contemporary-sensitive with HS cTnI immunoassay on hospital and laboratory workload.
methodsInformation on the total number of cTnI tests ordered, total number of blood samples collected, total number of CK-MB tests ordered, number of patients with the first HS-cTnI value below the limit of detection (LoD) and cumulative HS-cTnI values was extracted from the local hospital information system for the semesters before and after the HS method was introduced.
resultsAlthough the total emergency department (ED) visits modestly increased after introducing HS-cTnI, the number of total cTnI tests declined by over 10%. A substantial reduction of single-sample test requests was noted, accompanied by a considerable decline of 3- and 4-sample collections (i.e., -61% and -73%, respectively). A high percentage of patients (27.5%) displayed HS-cTnI values <LoD at admission, thus allowing safe discharge. The introduction of HS cTnI immunoassay was effective to collapse the number of CK-MB test requested and also generated favorable return of investment for the part of laboratory budget concerning cTnI testing (-3.2% of total costs for cTnI and -99.8% of total costs for CK-MB).
conclusionThe results of this study show substantial organizational and economic benefits by replacing contemporary-sensitive with HS cTnI immunoassays. (www.actabiomedica.it).
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