Evidence map›Paper›PMID 31909976›Full record

ArticleACS synthetic biology2020

Quantifying and Engineering Mucus Adhesion of Probiotics.

Zachary J S Mays, Todd C Chappell, Nikhil U Nair

Abstract read
In one paragraph

Article in ACS synthetic biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. DietaryInternational journal of molecular sciences · 2025
    Article
  8. Review
  9. The Effect of Probiotics and Microbiota on Nervous System and Mental Illnesses.Central nervous system agents in medicinal chemistry · 2025
    Review
  10. Article
  11. Engineering a Novel Probiotic Toolkit inACS synthetic biology · 2024
    Article
  12. Applied and environmental microbiology · 2024
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Characterization of lactic acid bacteria isolated from the poultry intestinal environment with anti-Salmonella activity in vitro.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zachary J S MaysDepartment of Chemical and Biological Engineering , Tufts University , Medford , Massachusetts 02155 , United States.
Todd C ChappellDepartment of Chemical and Biological Engineering , Tufts University , Medford , Massachusetts 02155 , United States.
Nikhil U NairDepartment of Chemical and Biological Engineering , Tufts University , Medford , Massachusetts 02155 , United States.ORCID 0000-0001-7737-1385

Funding

Metabolic engineering in humans: Altered gut microbes as a therapeutic platformDP2HD091798 · NICHD · TUFTS UNIVERSITY MEDFORD · PI NAIR, NIKHIL UNNI · 2016 to 2016
$2.3M
Toward Altered Probiotic Therapy for PhenylketonuriaR03HD090444 · NICHD · TUFTS UNIVERSITY MEDFORD · PI NAIR, NIKHIL UNNI · 2017 to 2018
$144k
NICHD NIH HHS DP2 HD091798NICHD NIH HHS R03 HD090444
6 · The paper itself

Abstract

Mucus in the gastrointestinal (GI) tract is the primary point-of-interaction between humans and their gut microbiota. This intimates that mucus not only ensures protection against endogenous and exogenous opportunists but also provisions for the human microbiota to reside and flourish. With the emergence of living therapeutics, engineered microbes can deliver and produce increasingly complex medicine, and controlling the mucoadhesive properties of different microbial chassis can dictate dose-response in a patient. Here we present a redesigned,

Indexed as

ProbioticsAnimalsBacterial AdhesionEscherichia coliFluoresceinsHumansLactococcus lactisMicroscopy, FluorescenceMucin-2MucusSwine6-carboxyfluoresceinFluoresceinsMucin-2cell adhesionlactic acid bacteriamicrobiomemucoadhesionmucusprobiotics

Identifiers

PMID31909976
PMCPMC7191639

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.