Evidence map›Paper›PMID 31909354›Full record

ArticleHepatology communications2020

Stathmin 1 Induces Murine Hepatocyte Proliferation and Increased Liver Mass.

Enpeng Zhao, Yang Shen, Muhammad Amir, Alton B Farris, Mark J Czaja

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. PD-1 regulates CD4Nature communications · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Enpeng ZhaoDepartment of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY.
Yang ShenDivision of Digestive Diseases Department of Medicine Emory University School of Medicine Atlanta GA.
Muhammad AmirDivision of Digestive Diseases Department of Medicine Emory University School of Medicine Atlanta GA.
Alton B FarrisDepartment of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta GA.
Mark J CzajaDivision of Digestive Diseases Department of Medicine Emory University School of Medicine Atlanta GA.ORCID https://orcid.org/0000-0003-2306-7219
Emory University · USIcahn School of Medicine at Mount Sinai · US

Funding

MODULATION OF ACUTE TOXIC LIVER INJURYR01DK044234 · NIDDK · YESHIVA UNIVERSITY · PI SRINIVASAN, SHANTHI K · 1992 to 2023
$7.6M
Research Training in Translational Gastroenterology and HepatologyT32DK108735 · NIDDK · EMORY UNIVERSITY · PI SUBRA KUGATHASAN · 2016 to 2026
$2.6M
HEPATOLOGY RESEARCHT32DK007218 · NIDDK · YESHIVA UNIVERSITY · PI CZAJA, MARK J · 1986 to 2011
$2.1M
Autophagy modulates liver injury and inflammation through cell signaling effectsR56DK044234 · NIDDK · EMORY UNIVERSITY · PI CZAJA, MARK J · 2018 to 2018
$454k
NIDDK NIH HHS R01 DK044234NIDDK NIH HHS R56 DK044234NIDDK NIH HHS T32 DK007218NIDDK NIH HHS T32 DK108735
6 · The paper itself

Abstract

The endogenous cellular signals that initiate the transition of hepatocytes from quiescence to proliferation remain unclear. The protein stathmin 1 (STMN1) is highly expressed in dividing cells, including hepatocytes, and functions to promote cell mitosis through physical interactions with tubulin and microtubules that regulate mitotic spindle formation. The recent finding that STMN1 mediates the resistance of cultured hepatocytes to oxidant stress led to an examination of the expression and function of this protein in the liver

Identifiers

PMID31909354
PMCPMC6939544
OpenAlexW2982906949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.