Evidence map›Paper›PMID 31909175›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019

Age-related retinal thickness in Down's syndrome: A high-risk population for dementia.

Madeleine J Walpert, Eduardo M Normando, Tiina Annus, Sally R Jennings, Liam R Wilson, Peter Watson, Shahid H Zaman, M Francesca Cordeiro, Anthony J Holland

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Increased choroidal thickness in adults with Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Madeleine J WalpertCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.
Eduardo M NormandoThe Imperial College Ophthalmic Research Group (ICORG), Imperial College London, South Kensington Campus, London, UK.
Tiina AnnusCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.
Sally R JenningsCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.
Liam R WilsonCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.
Peter WatsonMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Shahid H ZamanCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.
M Francesca CordeiroThe Imperial College Ophthalmic Research Group (ICORG), Imperial College London, South Kensington Campus, London, UK.
Anthony J HollandCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.
University of Cambridge · GBImperial College London · GBMRC Cognition and Brain Sciences Unit · GBWestern General Hospital · GB

Funding

Medical Research Council G1002252Medical Research Council MC_U105579212Medical Research Council MC_UU_00005/14
6 · The paper itself

Abstract

introductionPeople with Down's syndrome (DS) have a high prevalence of early-onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of preventative treatments. The retina, an extension of the brain, may provide a noninvasive imaging site.

methodsForty-nine adults with DS and 36 age-matched controls completed retinal nerve fibre layer (RNFL) assessments using optical coherence tomography. RNFL thickness was analyzed in relation to cognitive status and age and previously acquired cortical thickness and cerebral amyloid β binding data in a subgroup.

resultsRNFL thickness was greater in the DS group and did not show age-related thinning. RNFL correlated positively with cognitive scores and cortical thickness and was reduced in participants with positive cerebral amyloid β binding. DISCUSSION: Increased RNFL in adults with DS may represent early Alzheimer's disease-related changes. Thinning was present in those with cerebral amyloid β binding, independent of age.

Indexed as

Alzheimer's diseaseDementiaDown's syndromeOptical coherence tomographyRetina

Identifiers

PMID31909175
PMCPMC6939044
OpenAlexW2971589345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.