ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- Understanding brain resilience in superagers: a systematic review.Neuroradiology · 2021Pooled it
- Amyloid burden, brain metabolism, and gray matter volume in SuperAgers.Arquivos de neuro-psiquiatria · 2026Article
- Intrinsic functional connectivity strength of SuperAgers in the default mode and salience networks: Insights from ADNI.Aging brain · 2024Article
- Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study.BMC geriatrics · 2022Article
- Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology.Journal of Alzheimer's disease : JAD · 2022Review
- Structural integrity of the anterior mid-cingulate cortex contributes to resilience to delirium in SuperAging.Brain communications · 2022Article
- Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Synergistic Association between Plasma AβACS chemical neuroscience · 2021Article
- Longitudinal Trajectories in Cortical Thickness and Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy in Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Transfer learning-trained convolutional neural networks identify novel MRI biomarkers of Alzheimer's disease progression.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Assessment of Tau Tangles and Amyloid-β Plaques Among Super Agers Using PET Imaging.JAMA network open · 2020Article
- How Does the Mono-Triazole Derivative Modulate AβACS omega · 2020Article
- Hippocampal vascular reserve associated with cognitive performance and hippocampal volume.Brain : a journal of neurology · 2020Article
- White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging.Frontiers in aging neuroscience · 2020Article
- Comments about SuperAging and SuperAgers.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- SuperAging: Current findings yield future challenges-A response to Rogalski and Goldberg.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSuperior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether "SuperAgers" may be protected from Aβ-associated neurodegeneration.
methodsNeuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status.
resultsOf the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ- individuals displayed the slowest rates of atrophy. DISCUSSION: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ-) displayed reduced rates of cortical atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.