ArticleOpen forum infectious diseases2019
Benefits of Polymerase Chain Reaction Combined With Culture for the Diagnosis of Bone and Joint Infections: A Prospective Test Performance Study.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Clinical Utility of a Multiplex PCR Panel (BioFire Joint InfectionChildren (Basel, Switzerland) · 2024Article
- Unmasking Bartonella henselae infection in the shadows of long COVID thanks to clinical metagenomics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Article
- Diagnostic considerations in the clinical management of sudden swelling of the knee: a case report and review of the literature.Journal of medical case reports · 2024Review
- Optimized decision algorithm for the microbiological diagnosis of osteoarticular infections in adults using synovial fluid samples: a prospective study in two French hospitals including 423 samples of synovial fluid.Journal of bone and joint infection · 2024Article
- Advances in diagnosis and management of atypical spinal infections: A comprehensive review.North American Spine Society journal · 2023Article
- Real-Life Experience and Diagnostic Utility of the BioFire Joint Infection PCR Panel in Bone and Joint Infections: Analysis of a Prospective Validation Study.Infectious diseases and therapy · 2023Article
- Sonication versus the conventional method for evaluation of the dental microbiome: a prospective pilot study.BMC oral health · 2022Article
- Surveillance of osteoarticular infections caused byFrontiers in cellular and infection microbiology · 2022Article
- Challenging Methicillin Resistance Detection in Bone and Joint Infections: Focus on the MRSA/SA SSTI® Strategy.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe microbiological diagnosis of bone and joint infections (BJI) currently relies on cultures, and the relevance of molecular methods is still debated. The aim of this study was to determine whether polymerase chain reaction (PCR) could improve the etiological diagnosis of BJI.
methodsA prospective study was conducted during a 4-year period at Lariboisiere University Hospital (Paris, France), including patients with suspicion of infectious spondylodiscitis, septic arthritis, prosthetic joint infections, and respective noninfected groups. Clinical and radiological data were collected at inclusion and during follow-up. All samples were analyzed by conventional cultures and 16S ribosomal deoxyribonucleic acid (rDNA) gene (16S-PCR). Specific cultures and PCR targeting
resultsAfter expert committee analysis, 105 cases of BJI cases and 111 control patients were analyzed. The most common pathogens of BJI were staphylococci (30%),
conclusionsOur study showed the benefit of 16S-PCR and PCR targeting
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