Evidence map›Paper›PMID 31908963›Full record

ArticleUrology case reports2020

A case report of nivolumab-induced myasthenia gravis and myositis in a metastatic renal cell carcinoma patient.

Shotaro Nakanishi, Sho Nishida, Minoru Miyazato, Masato Goya, Seiichi Saito

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shotaro NakanishiDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Japan.
Sho NishidaDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Japan.
Minoru MiyazatoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, Japan.
Masato GoyaDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Japan.
Seiichi SaitoDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Japan.
University of the Ryukyus · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a 78-year-old male with renal cell carcinoma who developed myasthenia gravis complicated by myositis after nivolumab administration, which was verified by the presence of antibodies against the acetylcholine receptor. The initial symptom was posterior neck pain, and biochemical examination of blood showed elevated levels of hepatic enzymes and creatine phosphokinase. The level of antibody against the acetylcholine receptor increased 4.1-fold. His condition progressed rapidly resulting in respiratory failure 15 days after conservative therapy.

Indexed as

AChR, acetylcholine receptorCPK, creatine phosphokinaseICI, immune checkpoint inhibitorsIMDC, International Metastatic RCC Database ConsortiumirAE, immune-related adverse eventsMG, myasthenia gravisPD-1, programmed cell death-1PLE, pleuraPUL, pulmonaleRCC, renal cell carcinoma

Identifiers

PMID31908963
PMCPMC6940690
OpenAlexW2997345343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.