Evidence map›Paper›PMID 31908954›Full record

ArticleMolecular genetics and metabolism reports2020

Gene interactions observed with the HDL-c blood lipid, intakes of protein, sugar and biotin in relation to circulating homocysteine concentrations in a group of black South Africans.

Jacomina P du Plessis, Alida Melse-Boonstra, Lizelle Zandberg, Cornelie Nienaber-Rousseau

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Interaction betweenNutrients · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jacomina P du PlessisCentre of Excellence for Nutrition, North-West University, Private bag X6001, Nutrition, Box 594, Potchefstroom 2520, South Africa.
Alida Melse-BoonstraCentre of Excellence for Nutrition, North-West University, Private bag X6001, Nutrition, Box 594, Potchefstroom 2520, South Africa.
Lizelle ZandbergCentre of Excellence for Nutrition, North-West University, Private bag X6001, Nutrition, Box 594, Potchefstroom 2520, South Africa.
Cornelie Nienaber-RousseauCentre of Excellence for Nutrition, North-West University, Private bag X6001, Nutrition, Box 594, Potchefstroom 2520, South Africa.
North-West University · ZAWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElevated homocysteine (Hcy) is associated with several pathologies. Gene-diet interactions related to Hcy might be used to customize dietary advice to reduce disease incidence. To explore this possibility, we investigated interactions between anthropometry, biochemical markers and diet and single-nucleotide polymorphisms (SNPs) in relation to Hcy concentrations. Five SNPs of Hcy-metabolizing enzymes were analyzed in 2010 black South Africans.

resultsHcy was higher with each additional methylenetetrahydrofolate reductase (

conclusionsThe Hcy-SNP associations are modulated by diet and open up the possibility of invoking dietary interventions to treat hyperhomocysteinemia. Future intervention trials should further explore the observed gene-diet and gene-blood lipid interactions.

Indexed as

A, adenineAla, alanineAsp, aspartic acidBiotinBlood lipid–gene interactionsbp, base pairsCBS, cystathionine β synthaseC, cytosineCI, confidence intervalsCV, coefficient variationd, Cohen's d-valueES, effect sizeGene–diet interactionsGGT, gamma glutamyl transferaseG, guanineGLM, generalized linear modelGly, glycineHbA1c, glycated hemoglobinHcy, homocysteineHDL-c, high-density lipoprotein cholesterolHHcy, hyperhomocysteinemiaHWE, Hardy–Weinberg equilibriumHW, Hardy WeinbergHyperhomocysteinemiaID, identityIle, isoleucineins, insertionISAK, International Society for the Advancement of KinanthropometryLDL-c, low density lipoprotein cholesterolLD, pairwise linkage-disequilibriumMAF, minor allele frequencyMRC, Medical Research CouncilMTHFR, methylenetetrahydrofolate reductaseMT, mutant typeMTR, methionine synthaseNutrient–gene interactionsNutrigeneticsPA, physical activityPCR, polymerase chain reactionPrecision nutritionProteinPURE, Prospective Urban and Rural EpidemiologyQFFQ, quantitative food frequency questionnaireRFLP, restriction fragment length polymorphismSD, standard deviationsSE, standard errorSFA, saturated fatty acidsSNP, single-nucleotide polymorphismSugar%TCHO, percentage total carbohydrate intake%TE, percentage of total energyThr, threonineTHUSA, Transition and Health during Urbanization in South AfricaTotal homocysteineT, thymineVal, valineWT, wild type.

Identifiers

PMID31908954
PMCPMC6938949
OpenAlexW2997714724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.