Evidence map›Paper›PMID 31908948›Full record

ArticleIDCases2020

Ground-glass opacity as a paradoxical reaction in miliary tuberculosis: A case report and review of the literature.

Yuki Tokuyama, Takeshi Matsumoto, Yusuke Kusakabe, Naoki Yamamoto, Kensaku Aihara, Shinpachi Yamaoka, Michiaki Mishima

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuki TokuyamaDepartment of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.
Takeshi MatsumotoDepartment of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.
Yusuke KusakabeDepartment of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.
Naoki YamamotoDepartment of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.
Kensaku AiharaDepartment of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.
Shinpachi YamaokaDepartment of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.
Michiaki MishimaDepartment of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.
Saiseikai Ibaraki Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A paradoxical reaction (PR) is an excessive immune response occurring during antitubercular therapy (ATT), but is rare in patients with miliary tuberculosis. A 78-year-old woman complained of general malaise, loss of appetite, and fever for 10 days. Chest computed tomography (CT) showed diffuse, bilateral, discrete miliary nodules. The patient was treated with ATT for miliary tuberculosis. Nine days after starting the treatment, she developed a spiking fever and worsening malaise. Repeat CT showed new localized ground-glass opacity (GGO) in the right upper lobe. After excluding possible etiologies, she was diagnosed with PR due to ATT. She was successfully managed with oral prednisolone while continuing ATT. The GGO diminished and did not recur after discontinuation of the steroids. We reviewed 28 reported cases of miliary tuberculosis with a PR in patients not infected with human immunodeficiency virus. Those not on immunosuppressive therapy were likely to develop a PR early. This case illustrates that a PR may present as localized GGO in miliary tuberculosis in the lung of patients treated with ATT. In cases of a PR with marked symptoms, steroid therapy may be valuable.

Indexed as

ATT, antitubercular therapyCT, computed tomographyGGO, ground-glass opacityHIV, human immunodeficiency virusMiliary tuberculosisMycobacterium tuberculosisParadoxical reactionPR, paradoxical reaction

Identifiers

PMID31908948
PMCPMC6939021
OpenAlexW2994800740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.