ArticleBMJ open diabetes research & care2019
Diabetic retinopathy as an independent predictor of subclinical cardiovascular disease: baseline results of the PRECISED study.
Article in BMJ open diabetes research & care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Development and evaluation of a risk prediction model for diabetes mellitus type 2 patients with vision-threatening diabetic retinopathy.Frontiers in endocrinology · 2023Trial
- Retinal and coronary imaging in type 1 diabetes: links between retinopathy and subclinical cardiovascular disease.Frontiers in cardiovascular medicine · 2026Review
- The retina as a window into detecting subclinical cardiovascular disease in type 2 diabetes.Scientific reports · 2025Article
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- Retinal Imaging-Based Oculomics: Artificial Intelligence as a Tool in the Diagnosis of Cardiovascular and Metabolic Diseases.Biomedicines · 2024Review
- Two ferroptosis-specific expressed genes NOX4 and PARP14 are considered as potential biomarkers for the diagnosis and treatment of diabetic retinopathy and atherosclerosis.Diabetology & metabolic syndrome · 2024Article
- The prevention opportunities of retinopathy in diabetic patients - position paper endorsed by the Polish Lipid Association.Archives of medical science : AMS · 2024Article
- Diabetic Retinopathy and Cardiovascular Disease: A Literature Review [Response to Letter].Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- The coexistence of diabetic retinopathy and diabetic nephropathy is associated with worse kidney outcomes.Clinical kidney journal · 2023Article
- An Overview of Deep-Learning-Based Methods for Cardiovascular Risk Assessment with Retinal Images.Diagnostics (Basel, Switzerland) · 2022Review
- Predominant peripheral lesions in patients with diabetic retinopathy and its association with systemic comorbidities.Indian journal of ophthalmology · 2022Observational
- Cardiovascular Risk Stratification in Diabetic Retinopathy via Atherosclerotic Pathway in COVID-19/Non-COVID-19 Frameworks Using Artificial Intelligence Paradigm: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
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- Diabetic retinopathy predicts cardiovascular disease independently of subclinical atherosclerosis in individuals with type 2 diabetes: A prospective cohort study.Frontiers in cardiovascular medicine · 2022Article
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- Diabetic Retinopathy and Skin Tissue Advanced Glycation End Products Are Biomarkers of Cardiovascular Events in Type 2 Diabetic Patients.Journal of personalized medicine · 2021Article
- Review
- Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort.Scientific reports · 2021Article
- Relation between Retinopathy and Progression of Coronary Artery Calcium in Individuals with Versus Without Diabetes Mellitus (From the Multi-Ethnic Study of Atherosclerosis).The American journal of cardiology · 2021Article
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Authors and funding
17 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Detection of subclinical cardiovascular disease (CVD) has significant impact on the management of type 2 diabetes. We examined whether the assessment of diabetic retinopathy (DR) is useful for identifying patients at a higher risk of having silent CVD. Research design and methods: Prospective case-control study comprising 200 type 2 diabetic subjects without history of clinical CVD and 60 age-matched non-diabetic subjects. The presence of subclinical CVD was examined using two parameters: (1) calcium coronary score (CACs); (2) composite of CACs >400 UA, carotid plaque ≥3 mm, carotid intima-media thickness ratio >1, or the presence of ECG changes suggestive of previous asymptomatic myocardial infarction. In addition, coronary angio-CT was performed. DR was assessed by slit-lamp biomicroscopy and retinography. Results: Type 2 diabetic subjects presented higher CACs than non-diabetic control subjects (p<0.01). Age, male gender, and the presence of DR were independently related to CACs >400 (area under the receiver operating characteristic curve (AUROC) 0.76). In addition, an inverse relationship was observed between the degree of DR and CACs <10 AU. The variables independently associated with the composite measurement of subclinical CVD were age, diabetes duration, the glomerular filtration rate, microalbuminuria, and the presence of DR (AUROC 0.71). In addition, a relationship (p<0.01) was observed between the presence and degree of DR and coronary stenosis. Conclusions: The presence and degree of DR is independently associated with subclinical CVD in type 2 diabetic patients. Our results lead us to propose a rationalized screening for coronary artery disease in type 2 diabetes based on prioritizing patients with DR, particularly those with moderate-severe degree.
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