Evidence map›Paper›PMID 31908788›Full record

Trial reportBMJ open respiratory research2019

Predictive factors for sleep apnoea in patients on opioids for chronic pain.

Frances Chung, Jean Wong, Geoff Bellingham, Gerald Lebovic, Mandeep Singh, Rida Waseem, Philip Peng, Charles F P George, Andrea Furlan, Anuj Bhatia and 7 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02513836 (Development of an Innovative Opioid Safety Program in Pain Clinics), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02513836 nacompletednot on this map

Development of an Innovative Opioid Safety Program in Pain Clinics (Op-Safe): A Multi-Centre Project

TypeinterventionalSponsorUniversity Health Network, TorontoRan2015 to 2019Enrolled304ConditionsSleep Disordered BreathingArmsPre-education intervention, Post-education intervention
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Treatment for patients with sleep apnea on opioids for chronic pain: results of the OpSafe trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Trial
  3. Treatment of sleep-disordered breathing in opioid users with adaptive servo-ventilation: a subgroup analysis of the European READ-ASV registry.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Opioids and obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Review
  10. Article
  11. Review
  12. Article
  13. Thoughts on the 2019 American Academy of Sleep Medicine position statement on chronic opioid therapy and sleep.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Frances ChungDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Jean WongDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Geoff BellinghamDepartment of Anesthesia and Perioperative Medicine, St. Joseph's Health Care, Western University, London, Ontario, Canada.
Gerald LebovicApplied Health Research Centre, St Michael's Hospital, Institute for Health Policy Management and Evaluation, University of Toronto, Toronto, On, Canada.
Mandeep SinghDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Rida WaseemDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Philip PengDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Charles F P GeorgeDepartment of Medicine, University of Western Ontario, London, Ontario, Canada.
Andrea FurlanToronto Rehabilitation Institute, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Anuj BhatiaDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Hance ClarkeDepartment of Anesthesia and Pain Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, On, Canada.
David N JuurlinkDepartment of Medicine, Sunnybrook Hospital, University of Toronto, Toronto, Ontario, Canada.
Muhammad M MamdaniApplied Health Research Centre, St Michael's Hospital, Toronto, Ontario, Canada.
Richard HornerDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Beverley A OrserDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Clodagh M RyanSleep Research Laboratory, University Health Network, Toronto Rehabilitation Institute, Toronto, On, Canada.
Op-Safe Investigators
University of Toronto · CAToronto Western Hospital · CASt Joseph's Health Care · CAToronto Rehabilitation Institute · CAUniversity Health Network · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The risk of death is elevated in patients taking opioids for chronic non-cancer pain. Respiratory depression is the main cause of death due to opioids and sleep apnoea is an important associated risk factor. Methods: In chronic pain clinics, we assessed the STOP-Bang questionnaire (a screening tool for sleep apnoea; Results: Of 332 consented participants, 204 underwent polysomnography, and 120 (58.8%) had sleep apnoea (AHI ≥5) (72% obstructive, 20% central and 8% indeterminate sleep apnoea), with a high prevalence of moderate (23.3%) and severe (30.8%) sleep apnoea. The STOP-Bang questionnaire and SpO Conclusion: In patients on opioids for chronic pain, the STOP-Bang questionnaire and daytime SpO Trial registration number: NCT02513836.

Indexed as

AdultAgedAnalgesics, OpioidBlood Gas AnalysisChronic PainFemaleHumansMaleMiddle AgedOxygenOxyhemoglobinsPolysomnographyPrognosisProspective StudiesRespiratory InsufficiencyRisk AssessmentAnalgesics, OpioidOxygenOxyhemoglobinsChronic Painclinical epidemiologyOpioidssleep apnoea

Identifiers

PMID31908788
PMCPMC6936992
OpenAlexW2998685474

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.