ArticleJournal of animal science and biotechnology2020
Prepartum dietary energy intake alters adipose tissue transcriptome profiles during the periparturient period in Holstein dairy cows.
Article in Journal of animal science and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 65 citations in OpenAlex.
- Liver transcriptome dynamics in Holstein cows during the periparturient transition.Scientific reports · 2026Article
- Dose- and Duration-Dependent Effects of Propylene Glycol on Lipid Metabolism-Related mRNAs, Proteins, and Fatty Acids in the Adipose Tissue of Fattening Akkaraman Lambs.Food science & nutrition · 2025Article
- Dietary energy and protein gradients drive metabolic adaptation in growing-finishing yaks on the Qinghai-Tibet plateau.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Impact of feeding Murraya koenigii and Aegle marmelos leaves on metabolic and reproductive performance in crossbred cows.Tropical animal health and production · 2025Article
- Aloe arborescens supplementation in drying-off dairy cows: influence on rumen, rectum and milk microbiomes.Animal microbiome · 2024Article
- Effect of Parenteral Supplementation of Minerals and Vitamins on Oxidative Stress Biomarkers and Hepatic Fatty Acid Metabolism in Dairy Cows During the Transition Period.Biological trace element research · 2024Article
- Review: genetic background of milk fatty acid synthesis in bovines.Tropical animal health and production · 2023Review
- Ceramide on the road to insulin resistance and immunometabolic disorders in transition dairy cows: driver or passenger?Frontiers in immunology · 2023Review
- Immunometabolism in livestock: triggers and physiological role of transcription regulators, nutrients, and microbiota.Animal frontiers : the review magazine of animal agriculture · 2022Article
- Breed dependent regulatory mechanisms of beneficial and non-beneficial fatty acid profiles in subcutaneous adipose tissue in cattle with divergent feed efficiency.Scientific reports · 2022Article
- Branched-Chain Amino Acid Supplementation Alters the Abundance of Mechanistic Target of Rapamycin and Insulin Signaling Proteins in Subcutaneous Adipose Explants from Lactating Holstein Cows.Animals : an open access journal from MDPI · 2021Article
- Article
- Mismatch of Glucose Allocation between Different Life Functions in the Transition Period of Dairy Cows.Animals : an open access journal from MDPI · 2020Review
- Role of nutraceuticals during the transition period of dairy cows: a review.Journal of animal science and biotechnology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the study was to investigate the effect of energy overfeeding during the dry period on adipose tissue transcriptome profiles during the periparturient period in dairy cows.
methodsFourteen primiparous Holstein cows from a larger cohort receiving a higher-energy diet (1.62 Mcal of net energy for lactation/kg of dry matter; 15% crude protein) for ad libitum intake to supply 150% (OVR) or 100% (CTR) of energy requirements from dry off until parturition were used. After calving, all cows received the same lactation diet. Subcutaneous adipose tissue (SAT) biopsies were collected at - 14, 1, and 14 d from parturition (d) and used for transcriptome profiling using a bovine oligonucleotide microarray. Data mining of differentially expressed genes (DEG) between treatments and due to sampling time was performed using the Dynamic Impact Approach (DIA) and Ingenuity Pathway Analysis (IPA).
resultsThere was a strong effect of over-feeding energy on DEG with 2434 (False discovery rate-corrected
conclusionsData underscored a strong activation by overfeeding energy of anabolic processes in the SAT exclusively prepartum. The study confirmed that higher-energy diets prepartum drive a transcriptional cascade of events orchestrated in part by the activation of PPARγ that regulate preadipocyte differentiation and lipid storage in SAT. Novel aspects of SAT biology to energy overfeeding or change in physiologic state also were uncovered, including the role of amino acid metabolism, mTOR signaling, and the immune system.
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