Evidence map›Paper›PMID 31908633›Full record

ArticleHereditas2020

Profiling of the germline mutation

Yu Wu, Huanhuan Zhang, Xiaoling Weng, Honglian Wang, Qinghua Zhou, Ying Wu, Yi Shen, Zhen Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Impacts ofJournal of oncology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yu Wu1State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Department, School of Life Science, Fudan University, Shanghai, 200436 People's Republic of China.
Huanhuan ZhangAITA medical research institute, Shanghai, 200000 People's Republic of China.
Xiaoling WengAITA medical research institute, Shanghai, 200000 People's Republic of China.
Honglian WangAITA medical research institute, Shanghai, 200000 People's Republic of China.
Qinghua Zhou5Department of surgery, Luwan Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying Wu5Department of surgery, Luwan Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi Shen5Department of surgery, Luwan Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhen Hu4Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dongan Road, Xuhui, Shanghai, 200032 China.
Fudan University Shanghai Cancer Center · CNShanghai Jiao Tong University · CNRuijin Hospital · CNState Key Laboratory of Genetic Engineering

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer is a one of the malignant carcinomas partially caused by genetic risk factors. Germline

resultsA total of 23,481 clinically high-risk patients with breast cancer and 6489 healthy controls were recruited for p.Ile1845fs variant sequencing (either sanger or next generation sequencing). We identified 94 breast cancer patients (0.40%, 94/23481) as well as 11 healthy controls (0.17%, 11/6489) carried p.Ile1845fs variant.

conclusions

Indexed as

Germ-Line MutationAdultAgedAsian PeopleBRCA1 ProteinBreast NeoplasmsCase-Control StudiesChinaFemaleGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansMiddle AgedBRCA1 ProteinBRCA1 protein, humanBRCA1Breast cancerClinicopathologicalP.Ile1845fs

Identifiers

PMID31908633
PMCPMC6937991
OpenAlexW3002535940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.