ArticleCancer management and research2019
Metastasectomy Improves the Survival of Gastric Cancer Patients with Krukenberg Tumors: A Retrospective Analysis of 182 patients.
Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Prognostic Model for Survival After Upfront R0 Gastrectomy in Peritoneal Oligometastatic Gastric Cancer.Journal of gastric cancer · 2026Article
- Molecular characteristics and metastatic mechanism of patients diagnosed with Krukenberg tumor from gastric cancer.Journal of gastrointestinal oncology · 2026Article
- Strategies for the comprehensive treatment of gastric cancer ovarian metastasis.World journal of clinical oncology · 2025Review
- Comprehensive exome profiling identifiesTheranostics · 2025Article
- Practical management of oligometastatic gastric cancer.ESMO gastrointestinal oncology · 2024Review
- Krukenberg tumours: which patients should be considered for surgery?-a narrative literature review.Translational cancer research · 2024Review
- [European journal of nuclear medicine and molecular imaging · 2024Article
- Surgical resection and neoadjuvant therapy in patients with gastric cancer and ovarian metastasis: A real-world study.World journal of gastrointestinal surgery · 2024Article
- Significance of dysregulated M2 macrophage andTranslational cancer research · 2024Article
- Minimally Invasive Conversion Surgery for Unresectable Gastric Cancer with Splenic Metastasis and Splenic Vein Tumor Thrombus: A Case Report.Current oncology (Toronto, Ont.) · 2024Article
- Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment.Nature communications · 2024Article
- Oncological outcomes of conversion therapy in gastric cancer patients with peritoneal metastasis: a large-scale retrospective cohort study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Article
- Oligometastasis of Gastric Cancer: A Review.Cancers · 2024Review
- R0 resection of linitis plastica of the stomach with synchronous bilateral Krukenberg tumours in a young woman.Journal of surgical case reports · 2024Article
- Efficacy of chemotherapy combined with surgical resection for gastric cancer with synchronous ovarian metastasis: A propensity score matching analysis.Cancer medicine · 2023Article
- Transcriptomic characterization and construction of M2 macrophage-related prognostic and immunotherapeutic signature in ovarian metastasis of gastric cancer.Cancer immunology, immunotherapy : CII · 2023Article
- A retrospective study of clinicopathological characteristics and prognostic factors of Krukenberg tumor with gastric origin.Journal of gastrointestinal oncology · 2022Article
- Risk factors predicting the occurrence of metachronous ovarian metastasis of gastric cancer.Annals of translational medicine · 2021Article
- The diagnosis and outcome of Krukenberg tumors.Journal of gastrointestinal oncology · 2021Article
- Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics.Diagnostic pathology · 2021Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere is no consensus regarding whether metastasectomy in gastric cancer patients with Krukenberg tumors (KTs) is associated with survival benefits. The aim of this study was to evaluate the treatment of KTs of gastric origin in a large series of patients and to identify prognostic factors affecting survival. PATIENTS AND
methodsAll patients who were diagnosed with gastric cancer and ovarian metastases in a single medical center between January 2006 and December 2016 were identified and included. The patients were divided into two groups according to treatment modality: a metastasectomy group and a nonmetastasectomy group. Clinicopathological features and overall survival (OS) were compared between the groups.
resultsIn total, 182 patients were identified; 94 patients presented with synchronous KTs, and 88 developed metachronous KTs during follow-up. OS was significantly longer in the metastasectomy group than in the nonmetastasectomy group among those with synchronous (14.0 months vs 8.0 months; p = 0.001) and metachronous (14 months vs 8 months; p = 0.018) KTs. Multivariate analysis indicated that metastasectomy (hazard ratio [HR] 0.537; 95% confidence interval [CI] 0.344-0.839; p = 0.006), ascites (HR 1.523; 95% CI 1.058-2.193; p = 0.024), linitis plastica (HR 1.995; 95% CI 1.115-3.571; p = 0.020), and systemic chemotherapy (HR 0.456; 95% CI 0.280-0.742; p = 0.002) were independent predictors of OS.
conclusionMetastasectomy combined with systemic chemotherapy should be performed in gastric cancer patients with synchronous or metachronous KTs. Metastasectomy, systemic therapy, linitis plastica, and ascites are prognostic factors for OS. Further prospective randomized studies are needed.
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