ArticleIntegrated blood pressure control2019
Association of Chronic Khat Chewing with Blood Pressure and Predictors of Hypertension Among Adults in Gurage Zone, Southern Ethiopia: A Comparative Study.
Article in Integrated blood pressure control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Does regular Khat (Catha edulis) chewing in adults increase the risk of hypertension compared to non-use? A systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Article
- Self-Monitoring of Blood Pressure in Yemen: Preliminary Insights Into Knowledge, Attitudes and Practices of Hypertensive Patients.Vascular health and risk management · 2025Article
- Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Scoping Review.Cardiovascular toxicology · 2024Article
- Levels and Health Risk Assessments of Heavy Metals in Khat and Its Support Soil in Algesachi, Ilu Ababor, Ethiopia.Environmental health insights · 2024Article
- Exploring the perception of key stakeholders toward khat policy approaches in Ethiopia: a qualitative study.Harm reduction journal · 2023Article
- Adverse Effects of Chewing Khat (Catha edulis): A Community-based Study in Ethiopia.Oman medical journal · 2023Article
- Factors Associated with Anxiety During COVID-19 Pandemic and Its Association with Hypertension in Saudi Arabia.Patient preference and adherence · 2023Article
- The impact of khat chewing on heart activity and rehabilitation therapy from khat addiction in healthy khat chewers.Scientific reports · 2022Article
- Impact of khat leaves on glycosylated haemoglobin and lipid profile in healthy individuals in Dire Dawa, Ethiopia.SAGE open medicine · 2022Article
- Risks of khat chewing on the cardiovascular, nervous, gastrointestinal, and genitourinary systems: A narrative review.Journal of family medicine and primary care · 2022Review
- The Prevalence of Hypertension and Associated Risk Factors among Secondary School Teachers in Bahir Dar City Administration, Northwest Ethiopia.International journal of hypertension · 2021Article
- Article
- Prevalence of Hypertension and Associated Factors Among Adults in Debre Berhan Town, North Shoa Zone, Ethiopia, 2020.Vascular health and risk management · 2021Article
- Review
- Undiagnosed Hypertension and Associated Factors Among Adults in Hawela Tula Sub-City, Hawassa, Southern Ethiopia: A Community-Based Cross-Sectional Study.Risk management and healthcare policy · 2020Article
- The Impact of Khat (Journal of medical ultrasoundArticle
- The association between dolutegravir-based antiretrovirals and high blood pressure among adults with HIV in southern Ethiopia: a cross-sectional study.Therapeutic advances in infectious diseaseArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe leaves of the Khat plant contain amphetamine-like compounds which are implicated in the development of hypertension. The increase in blood pressure coincides with the plasma cathinone level. Other factors associated with hypertension are being overweight, obesity, cigarette smoking, alcohol use, physical inactivity, unhealthy diet, and stress. Thus, this study assessed the association of chronic khat chewing with hypertension and other factors associated with hypertension. PATIENTS AND
methodsAcommunity based comparative cross-sectional study was undertaken from October 5, 2018 to February 15, 2019 in Gurage zone, southern Ethiopia. A total of 1200 adults (600 chewers and 600 non-chewers) aged 18 - 65 years were selected using a convenience sampling method. The data was collected by an interviewer-administered questionnaire plus physical measurements and were carried out at a fixed time of the day in the morning (7: 00 am-10:00 am). Linear regression and binary logistic regression analysis were performed to identify the determinant factors of blood pressure. The test of statistically significant association was declared by using 95% CI and p-value less than 0.05.
resultsA total of 1198 adults participated in the study giving a response rate of 99.8%. The mean age of Khat chewers were 34 (± 11.27) and non-chewers were 34.73 (± 11.48) years. The mean values of systolic blood pressure and diastolic blood pressure were higher in chewers than in non-chewers (p < 0.001). The prevalence of diastolic blood pressure > 80mmHg was significantly higher among Khat chewers than in non-chewers (17.4% versus 8.7%, p < 0.001). The duration of Khat chewing was significantly associated with systolic blood pressure (Beta coefficient = 0.83, p < 0.001) and diastolic blood pressure (Beta coefficient = 0.51, p < 0.001). The sex, age, BMI and alcohol were significantly associated with both systolic and diastolic blood pressure.
conclusionChronic Khat chewing, male sex, BMI and alcohol were associated with increased systolic and diastolic blood pressure. To assess the cause and effect relationship between chronic Khat chewing and hypertension further studies with better defined cohorts and basic science studies need to be undertaken.
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