Evidence map›Paper›PMID 31908456›Full record

ArticleInternational journal of nanomedicine2019

808 nm Near-Infrared Light-Excited UCNPs@mSiO

Jiahe Hu, Jialan Shi, Yingqian Gao, Wei Yang, Ping Liu, Qinghao Liu, Fei He, Chunxu Wang, Tao Li, Rui Xie and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jiahe Hu *Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China.
Jialan ShiDepartment of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People's Republic of China.
Yingqian GaoDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China.
Wei YangDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China.
Ping LiuDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China.
Qinghao LiuDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China.
Fei HeKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, People's Republic of China.
Chunxu WangDepartment of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People's Republic of China.
Tao LiDepartment of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People's Republic of China.
Rui XieDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China.ORCID 0000-0003-0357-6702
Jiuxin ZhuDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People's Republic of China.
Piaoping Yang *Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, People's Republic of China.
Harbin Medical University · CNHarbin Engineering University · CNBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is important to explore effective treatment for liver cancer. Photodynamic therapy (PDT) is a novel technique to treat liver cancer, but its clinical application is obstructed by limited depth of visible light penetration into tissue. The near-infrared (NIR) photosensitizer is a potential solution to the limitations of PDT for deep tumor tissue treatment. PURPOSE: We aimed to investigate 808 nm NIR light-excited UCNPs@mSiO

methodsIn our study, 808 nm NIR light-excited upconversion nanoparticles (UCNPs) were simultaneously loaded with the photosensitizer chlorin e6 (Ce6) and the antibody glypican-3 (GPC3), which is overexpressed in hepatocellular carcinoma cells. The multitasking UCNPs@mSiO

resultsWe found that the UCNPs@mSiO

conclusionWe believe that the utilization of 808 nm NIR excited UCNPs@mSiO

Indexed as

AnimalsAntibodiesCell Line, TumorChlorophyllidesGlypicansHemolysisHep G2 CellsHumansLightLiver NeoplasmsMaleMice, NudeNanoparticlesPhotochemotherapyPhotosensitizing AgentsPorphyrinsAntibodiesChlorophyllidesGlypicansGPC3 protein, humanPhotosensitizing AgentsphytochlorinPorphyrins808 nm NIRGPC3liver cancerphotodynamic therapytargeted therapyupconversion nanoparticles

Identifiers

PMID31908456
PMCPMC6929933
OpenAlexW2996128712

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.