Evidence map›Paper›PMID 31908446›Full record

ArticleInternational journal of nanomedicine2019

Enhanced Gene Delivery in Bacterial and Mammalian Cells Using PEGylated Calcium Doped Magnetic Nanograin.

Ehsan Hashemi, Hossein Mahdavi, Jafar Khezri, Farideh Razi, Mehdi Shamsara, Abbas Farmany

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ehsan HashemiNational Research Center for Transgenic Mouse & Animal Biotechnology Division, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Hossein MahdaviSchool of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Jafar KhezriNational Research Center for Transgenic Mouse & Animal Biotechnology Division, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Farideh RaziEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi ShamsaraNational Research Center for Transgenic Mouse & Animal Biotechnology Division, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Abbas FarmanyDental Implant Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID 0000-0002-9671-1696
National Institute of Genetic Engineering and Biotechnology · IRHamedan University of Medical Sciences · IRTehran University of Medical Sciences · IRUniversity of Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBeyond viral carriers which have been widely used in gene delivery, non-viral carriers can further improve the delivery process. However, the high cytotoxicity and low efficiency impedes the clinical application of non-viral systems. Therefore, in this work, we fabricated polyethylene glycol (PEG) coated, calcium doped magnetic nanograin (PEG/Ca(II)/Fe

methodsMonodisperse magnetic nanograins (MNGs) with tunable size were synthesized by a solvothermal method. The citrate anions on the spherical surface of MNGs capture Ca

resultsDLS spectra and TEM images confirmed a thin layer of PEG on the nanocarrier surface. Shifting the zeta potential in the biological pH window from -23.9 mV (for Fe

conclusionPEGylated calcium doped magnetic nanograin enhanced PUC19 plasmid expression into

Indexed as

Gene Transfer TechniquesAnimalsCalciumDynamic Light ScatteringEscherichia coliGreen Fluorescent ProteinsHEK293 CellsHumansMagnetic PhenomenaMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionNanoparticlesPlasmidsPolyethylene GlycolsSpectroscopy, Fourier Transform InfraredCalciumGreen Fluorescent ProteinsPolyethylene Glycolscalcium doped magnetic nanograinscytotoxicitygene expression

Identifiers

PMID31908446
PMCPMC6928224
OpenAlexW2995391579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.