Observational studyInternational journal of chronic obstructive pulmonary disease2019
Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis.
Erratum issued Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in International journal of chronic obstructive pulmonary disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- New spirometry recommendations from the Brazilian Thoracic Association - 2024 update.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Guideline
- Lung Function and the Risk of Exacerbation in the β-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Trial.Annals of the American Thoracic Society · 2022Trial
- Clinical characteristics, symptom burden, and pulmonary function trajectories of spirometry- and MMEF-defined bronchodilator responsiveness in COPD: a single-center prospective study.Journal of thoracic disease · 2026Article
- Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort.Annals of the American Thoracic Society · 2025Article
- Prevalence of Bronchodilator Responsiveness: A Comparison of Old Versus New Criteria.Respiratory care · 2024Article
- Article
- Clinical characterization and outcomes of impulse oscillometry-defined bronchodilator response: an ECOPD cohort-based study.Respiratory research · 2024Observational
- Prevalence, Diagnostic Utility and Associated Characteristics of Bronchodilator Responsiveness.American journal of respiratory and critical care medicine · 2024Article
- [Effects of type 2 inflammation on bronchodilator responsiveness of large and small airways in chronic obstructive pulmonary disease].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Chronic obstructive pulmonary disease (COPD) and COPD-like phenotypes.Frontiers in medicine · 2024Review
- Breathing, Obstruction, Restriction, and Gas Exchange: A Pulmonary Function Testing Interpretation Framework for Novice Learners.ATS scholar · 2023Article
- Article
- Machine learning for screening of at-risk, mild and moderate COPD patients at risk of FEVFrontiers in physiology · 2023Article
- Association of CT phenotype with pulmonary function in patients with chronic obstructive pulmonary disease and influencing factors of prognosis.American journal of translational research · 2023Article
- Article
- Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study.American journal of respiratory and critical care medicine · 2022Observational
- Bronchodilator Responsiveness Defined by the 2005 and 2021 ERS/ATS Criteria in Patients with Asthma as Well as Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022Article
- From GOLD 0 to Pre-COPD.American journal of respiratory and critical care medicine · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
35 authors at 13 institutions in 1 country.
Igor Z BarjaktarevicDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8096-0858
Russell G BuhrDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6159-7435
Xiaoyan WangDepartment of General Internal Medicine and Health Services Research, University of California, Los Angeles, Los Angeles, CA, USA.
Scott HuDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
David CouperDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-4313-9235
Wayne AndersonDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Richard E KannerDepartment of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-6915-599X
Robert Paine IiiDepartment of Medicine, University of Utah, Salt Lake City, UT, USA.
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-8418-4497
Nirav R BhaktaDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2135-7012
Mehrdad ArjomandiDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0116-9217
Robert J KanerDepartment of Medicine, Weill Cornell Weill Cornell Medical Center, New York, NY, USA.ORCID 0000-0003-0527-576X
Cheryl S PirozziDepartment of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-1533-1916
Jeffrey L CurtisDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5191-4847
Wanda K O'NealDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Prescott G WoodruffDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
MeiLan K HanDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
Fernando J MartinezDepartment of Medicine, Weill Cornell Weill Cornell Medical Center, New York, NY, USA.ORCID 0000-0002-2412-3182
Nadia HanselDepartment of Medicine, John Hopkins University, Baltimore, MD, USA.
James Michael WellsDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Victor E OrtegaDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Eric A HoffmanDepartment of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-8456-9437
Claire M DoerschukDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Victor KimDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0002-1385-1571
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
M Bradley DrummondDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-6968-4610
Russell BowlerDepartment of Medicine, National Jewish Health Systems, Denver, CO, USA.
Gerard CrinerDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Stephanie A ChristensonDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Bonnie RonishDepartment of Medicine, University of Utah, Salt Lake City, UT, USA.
Stephen P PetersDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-4176-7999
Jerry A KrishnanDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0001-5525-4778
Donald P TashkinDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Christopher B CooperDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)
University of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USUniversity of California, San Francisco · USUniversity of Utah · USUniversity of Alabama at Birmingham · USCornell University · USTemple University · USUniversity of Michigan · USWake Forest University · USJohns Hopkins University · USNational Jewish Health · USUniversity of Illinois Chicago · USUniversity of Iowa · US
Funding
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MNRSA Training CoreTL1TR001883 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEX BUI, Nina Thawata Harawa · 2016 to 2026
$8.6MTRAINING IN RESPIRATORY AND ENVIRONMENTAL MEDICINET32HL007106 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES, DOERSCHUK, CLAIRE M · 1985 to 2021
$7.3MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MParametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0MCathelicidin and Vitamin D: Impact on Populations At-Risk and with COPDR01HL125432 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DRUMMOND, MICHAEL BRADLEY · 2015 to 2019
$3.1MUltra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0MDefining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MIdentifying the Th2 endotype in COPD: clinical and pathologic implicationsK23HL123778 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTENSON, STEPHANIE A · 2015 to 2019
$847kThe Role of PGP in COPD-associated Pulmonary HypertensionK08HL123940 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2014 to 2018
$744kCSRD VA I01 CX000911NCATS NIH HHS TL1 TR001883NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K08 HL123940NHLBI NIH HHS K23 HL123778NHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL138188NHLBI NIH HHS R01 HL122438NHLBI NIH HHS R01 HL125432NHLBI NIH HHS T32 HL007106NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIH HHS S10 OD018526
Abstract
Objective: Bronchodilator responsiveness (BDR) is prevalent in COPD, but its clinical implications remain unclear. We explored the significance of BDR, defined by post-bronchodilator change in FEV Methods: We analyzed 2974 participants from a multicenter observational study designed to identify varying COPD phenotypes (SPIROMICS). We evaluated the association of BDR with baseline clinical characteristics, rate of prospective exacerbations and mortality using negative binomial regression and Cox proportional hazards models. Results: A majority of COPD participants exhibited BDR (52.7%). BDR Conclusion: With advanced airflow obstruction in COPD, BDR Clinical trials registration: ClinicalTrials.gov: NCT01969344T4.
Indexed as
Airway ObstructionAsthmaBronchodilator AgentsPulmonary Disease, Chronic ObstructivePulmonary EmphysemaAdultBiological Variation, PopulationDisease ProgressionFemaleForced Expiratory VolumeHumansMaleMiddle AgedPrevalenceProportional Hazards ModelsTreatment OutcomeBronchodilator Agentsbronchodilator responsivenessFEV1FVCinspiratory capacitySPIROMICS
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.