ArticlePatient preference and adherence2019
Initiation And Persistence With Antiplatelet Agents Among The Patients With Acute Coronary Syndromes: A Retrospective, Observational Database Study In China.
Article in Patient preference and adherence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Quality of care for secondary cardiovascular disease prevention in 2009-2017: population-wide cohort study of antiplatelet therapy use in Scotland.BMJ quality & safety · 2024Article
- Non-persistence with multiple secondary prevention medications for peripheral arterial disease among older hypertensive patients.Frontiers in pharmacology · 2024Article
- Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myeloma.Frontiers in pharmacology · 2023Article
- Antithrombotic strategy and its relationship with outcomes in patients with atrial fibrillation and chronic coronary syndrome.Journal of thrombosis and thrombolysis · 2022Article
- Comparison of prognosis and outcomes of catheter ablation versus drug therapy in patients with atrial fibrillation and stable coronary artery disease: A prospective propensity-score matched cohort study.Clinical cardiology · 2021Article
- Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease.Frontiers in pharmacology · 2021Article
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4 authors.
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Abstract
objectivesTo investigate the initiation and persistence of antiplatelet agents and the associated factors for patients with acute coronary syndromes (ACS) in Tianjin, China.
methodsData were obtained from Tianjin Urban Employee Basic Medical Insurance database (2011-2015). Adult patients who were discharged alive after the first ACS-related hospitalization (index hospitalization) between January 2012 and December 2014 were included. Patients who initiated with antiplatelet therapy, including aspirin monotherapy, clopidogrel monotherapy, or dual antiplatelet with aspirin and clopidogrel at discharge or within the initial 30-day follow-up after discharge were further identified. Patients with no gaps of ≥30 days in antiplatelet therapy were deemed persistent. The logistic model and Cox model were used to explore the associated factors of initiation and persistence with antiplatelet agents, respectively.
resultsIn total, 21,450 patients (64.6±10.7 years; 46.0% female) were included. Only 70.3% (N=15,071) of them initiated with antiplatelet agents within the initial 30-day follow-up; 85.0% (N=12,809) of the initial users discontinued their antiplatelet therapy, and the average time to discontinuation was 117.4±119.7 days. The patients who had prior antiplatelet agents utilization (Odds ratio [95% CI]=1.93 [1.78-2.09]; hazard ratio [95% CI]=0.78 [0.74-0.81]), received percutaneous coronary intervention (PCI) during the baseline period (OR=1.47 [1.26-1.73]; HR=0.91 [0.84-0.97]) or index hospitalization (OR=22.40 [18.63-26.92]; HR=0.51 [0.49-0.53]) were more likely to initiate and persist with antiplatelet agents, while the female (OR=0.75 [0.70-0.81]; HR=1.22 [1.88-1.27]) patients were less likely to initiate and persist with antiplatelet agents.
conclusionThe initiation and persistence with antiplatelet agents are poor among the ACS patients in Tianjin. Females are associated with poorer initiation and persistence, while prior antiplatelet agents use and receiving PCI during baseline period or index hospitalization are associated with better initial use and better persistence.
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