Evidence map›Paper›PMID 31908386›Full record

ArticleJournal of medical physics

Establishment of a New Three-Dimensional Dose Evaluation Method Considering Variable Relative Biological Effectiveness and Dose Fractionation in Proton Therapy Combined with High-Dose-Rate Brachytherapy.

Daisuke Kobayashi, Tomonori Isobe, Kenta Takada, Yutaro Mori, Hideyuki Takei, Hiroaki Kumada, Satoshi Kamizawa, Tetsuya Tomita, Eisuke Sato, Hiroshi Yokota and 1 more

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Article in Journal of medical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Daisuke KobayashiGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Tomonori IsobeGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Kenta TakadaGraduate School of Radiological Technology, Gunma Prefectural College of Health Sciences, Gunma, Japan.
Yutaro MoriGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Hideyuki TakeiGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Hiroaki KumadaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Satoshi KamizawaProton Medical Research Center, University of Tsukuba Hospital, Ibaraki, Japan.
Tetsuya TomitaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Eisuke SatoFaculty of Health Science, Juntendo University, Tokyo, Japan.
Hiroshi YokotaDepartment of Radiology, University of Tsukuba Hospital, Ibaraki, Japan.
Takeji SakaeGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to evaluate the influence of variable relative biological effectiveness (RBE) of proton beam and dose fractionation has on dose distribution and to establish a new three-dimensional dose evaluation method for proton therapy combined with high-dose-rate (HDR) brachytherapy. MATERIALS AND

methodsTo evaluate the influence of variable RBE and dose fractionation on dose distribution in proton beam therapy, the depth-dose distribution of proton therapy was compared with clinical dose, RBE-weighted dose, and equivalent dose in 2 Gy fractions using a linear-quadratic-linear model (EQD2

resultsThe RBE-weighted dose increased at the distal of the spread-out Bragg peak (SOBP). With the difference in the dose fractionation taken into account, the EQD2

conclusionsOur dose evaluation method can evaluate the EQD2

Indexed as

Dose fractionationhigh-dose-rate brachytherapylinear-quadratic-linear modelproton therapyrelative biological effectiveness

Identifiers

PMID31908386
PMCPMC6936203

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.