ArticleBrain and behavior2020
Early and very early-onset schizophrenia compared with adult-onset schizophrenia: French FACE-SZ database.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Prevalence of Attention Deficit Hyperactivity Disorder in Psychotic Disorders: Systematic Review and Meta-analysis.Schizophrenia bulletin · 2025Pooled it
- Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Knowledge domain and trends in treatment-resistant schizophrenia (TRS) research based on CiteSpace bibliometrics analysis.Frontiers in pharmacology · 2024Pooled it
- Clinical features and comorbidity in very early-onset schizophrenia: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Identification of hub genes involved in early-onset schizophrenia: from genetic susceptibility to predicted regulated gene expression.Molecular psychiatry · 2026Article
- Neurocognition and social cognition as risk markers in adolescents: a comparative study of asymptomatic siblings of Early-Onset Schizophrenia and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Age-Dependent Corpus Callosum Thickness Abnormalities and Clinical Implications in Treatment-Naïve First-Episode Schizophrenia.Alpha psychiatry · 2026Article
- Early versus adult onset of schizophrenia: an examination of premorbid and current IQ.Schizophrenia research. Cognition · 2026Article
- DNA methylation signatures associated with early-onset schizophrenia in Chinese patients.Translational psychiatry · 2026Article
- Exploring Primary and Interaction Effects of Minor Physical Anomalies: Development and Validation of Prediction Models Using Explainable Machine Learning Algorithms for Early-Onset Schizophrenia.Schizophrenia bulletin · 2026Article
- Machine learning helps predict early onset psychosis with serum protein biomarkers, neuropsychometry, and clinicodemographic data.Scientific reports · 2025Article
- Neurocognitive dysfunctions in childhood-onset schizophrenia: A systematic review.Schizophrenia research. Cognition · 2025Review
- Identification of Hub Genes Involved in Early-onset Schizophrenia: From Genetic Susceptibility to Predicted Regulated Gene Expression.Research square · 2025Article
- The neurodevelopmental regulatory role and clinical value of hsa-circ-CORO1C-hsa-miR-708-3p-JARID2 + LNPEP axis in early-onset schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia.World journal of psychiatry · 2024Article
- Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?European child & adolescent psychiatry · 2024Article
- Challenges and opportunities in the diagnosis and treatment of early-onset psychosis: a case series from the youth affective disorders clinic in Stockholm, Sweden.Schizophrenia (Heidelberg, Germany) · 2024Article
- Schizophrenia in children, adults and older people with intellectual disability compared with the general population: a Swedish register study (IDcare).General psychiatry · 2024Article
- Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.Frontiers in psychiatry · 2024Article
- History of learning disorders is associated with worse cognitive and functional outcomes in schizophrenia: results from the multicentric FACE-SZ cross-sectional dataset.European archives of psychiatry and clinical neuroscience · 2023Article
Corrections and comments
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27 authors.
Funding
Abstract
objectiveTo compare the clinical symptomatology in patients with Early-Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551).
methodIn a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were assessed using standardized and extensive clinical and neuropsychological batteries: AOS with onset ≥ 18 years and EOS with onset < 18 years (including 22 VEOS < 13 years).
resultsThe importance of better diagnosing EOS group, and in particularly VEOS, appeared in a longer DUP Duration of Untreated Psychosis (respectively, 2.6 years ± 4.1 and 8.1 years ± 5.7 vs. 1.0 years ± 2.5), more severe symptomatology (PANSS Positive And Negative Syndrome Scale scores), and lower educational level than the AOS group. In addition, the VEOS subgroup had a more frequent childhood history of learning disabilities and lower prevalence of right-handedness quotient than the AOS.
conclusionThe study demonstrates the existence of an increased gradient of clinical severity from AOS to VEOS. In order to improve the prognosis of the early forms of schizophrenia and to reduce the DUP, clinicians need to pay attention to the prodromal manifestations of the disease.
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