ArticleJournal of child psychology and psychiatry, and allied disciplines2020
Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prenatal Exposure to Air Pollutants and Attentional Deficit Hyperactivity Disorder Development in Children: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Impact of polycyclic aromatic hydrocarbon exposure on cognitive function and neurodegeneration in humans: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Prenatal and early life phthalate exposure and early life stress: no interactions with adolescent internalizing symptoms.Environment international · 2026Article
- The joint effects of exposure to prenatal pesticides and psychosocial factors on epigenetic age acceleration in the first 5 years of life in a South African birth cohort.medRxiv : the preprint server for health sciences · 2026Article
- Prenatal Exposure to Air Pollution and Risk for Attention-Deficit/hyperactivity Disorder in Children.Research on child and adolescent psychopathology · 2026Article
- Combined prenatal exposure to airborne polycyclic aromatic hydrocarbons and maternal distress is associated with childhood irritability.Frontiers in public health · 2026Article
- Prenatal environmental risk for adolescent attention, thought, and substance use problems: A mixtures approach to coexposure and psychiatric comorbidities.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Article
- Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Cumulative risk assessment as the pathway to public health protection for behavioral neurotoxicity.Neurotoxicology · 2025Review
- Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children's learning difficulties.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage.Developmental cognitive neuroscience · 2025Article
- The next 1000 days: building on early investments for the health and development of young children.Lancet (London, England) · 2024Review
- Joint effects of indoor air pollution and maternal psychosocial factors during pregnancy on trajectories of early childhood psychopathology.American journal of epidemiology · 2024Article
- Prenatal polycyclic aromatic hydrocarbon exposure and neurodevelopment among children in Puerto Rico.Chemosphere · 2024Article
- Prenatal exposure to polycyclic aromatic hydrocarbons and executive functions at school age: Results from a combined cohort study.International journal of hygiene and environmental health · 2024Article
- Early life exposure to air pollution and psychotic-like experiences, emotional symptoms, and conduct problems in middle childhood.Social psychiatry and psychiatric epidemiology · 2024Article
- Major air pollution and climate policies in NYC and trends in NYC air quality 1998-2021.Frontiers in public health · 2024Article
- The Role of Environmental Chemicals in the Etiology of Learning Difficulties: A Novel Theoretical Framework.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundRisk for childhood psychopathology is complex and multifactorial, implicating direct and interacting effects of familial and environmental factors. The role of environmental neurotoxicants in psychiatric risk is of growing concern, including polycyclic aromatic hydrocarbons (PAH), common in air pollution. Prenatal PAH exposure is linked to adverse physical, behavioral, and cognitive outcomes as well as increasing psychiatric risk. It is unclear whether environmental exposures, like PAH, magnify the effects of exposure to early life stress (ELS), a critical risk factor for psychopathology. The current work aimed to test potential interactions between prenatal PAH exposure and psychosocial/socioeconomic stress on psychiatric symptoms in school-age children.
methodsData were from the Columbia Center for Children's Environmental Health Mothers and Newborns longitudinal birth cohort study. Prenatal PAH exposure was ascertained though air monitoring during pregnancy and maternal PAH-DNA adducts at delivery. Mothers reported on ELS (child age 5) and on child psychiatric symptoms across childhood (child age 5, 7, 9, and 11) using the Child Behavior Checklist (CBCL).
resultsSignificant prenatal airborne PAH × ELS interactions (FDR-corrected) predicted CBCL Attention (β = 0.22, t(307) = 3.47, p < .001, p
conclusionsPrenatal exposure to PAH, a common neurotoxicant in air pollution, may magnify or sustain the effects of early life psychosocial/socioeconomic stress on psychiatric outcomes later in child development. This work highlights the critical role of air pollution exposure on child mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.