Evidence map›Paper›PMID 31907928›Full record

Trial reportClinical and experimental immunology2020

Phenotypic shift of small intestinal intra-epithelial type 1 innate lymphoid cells in celiac disease is associated with enhanced cytotoxic potential.

M Uhde, X Yu, A Bunin, C Brauner, S K Lewis, B Lebwohl, S Krishnareddy, A Alaedini, B Reizis, S Ghosh and 2 more

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

M Uhde *Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
X Yu *Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-5659-1418
A BuninDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
C BraunerDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
S K LewisDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
B LebwohlDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
S KrishnareddyDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
A AlaediniDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
B ReizisDepartment of Pathology, Department of Medicine, New York University Langone Medical Center, New York, NY, USA.
S GhoshDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
P H GreenDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
G BhagatDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · USColumbia University · USNYU Langone Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The small intestinal (SI) epithelium harbors a heterogeneous population of lymphocytes that mediate mucosal damage and repair in celiac disease (CD). The composition and roles of human proximal SI intra-epithelial innate lymphoid cells (ILCs), and their alterations in CD, are not well understood. We report that duodenal intra-epithelial ILCs predominantly consist of natural killer (NK)p44

Indexed as

Celiac DiseaseDuodenumIntestinal MucosaLymphocytesAdolescentAdultCell TransdifferentiationChildChild, PreschoolFemaleHumansImmunity, InnateInfantMaleautoimmunitycell surface moleculeshumaninflammationinnate lymphoid cells

Identifiers

PMID31907928
PMCPMC7160661
OpenAlexW3000230448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.